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mapk10 mitogen-activated protein kinase 10 [ Danio rerio (zebrafish) ]

Gene ID: 569698, updated on 27-Mar-2024

Summary

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Official Symbol
mapk10provided by ZNC
Official Full Name
mitogen-activated protein kinase 10provided by ZNC
Primary source
ZFIN:ZDB-GENE-051120-117
See related
Ensembl:ENSDARG00000102730 AllianceGenome:ZFIN:ZDB-GENE-051120-117
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:123234
Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. In mammals, this kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Orthologs
human mouse all
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Genomic context

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See mapk10 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (9576133..9717404)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (9483018..9624665)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene SDA1 domain containing 1 Neighboring gene protein tyrosine phosphatase non-receptor type 13 Neighboring gene Rho GTPase activating protein 24 Neighboring gene endothelial cell-specific molecule 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A Novel Zebrafish ret Heterozygous Model of Hirschsprung Disease Identifies a Functional Role for mapk10 as a Modifier of Enteric Nervous System Phenotype Severity. Heanue TA, et al. PLoS Genet, 2016 Nov. PMID 27902697, Free PMC Article
  2. JNK-interacting protein 3 mediates the retrograde transport of activated c-Jun N-terminal kinase and lysosomes. Drerup CM, et al. PLoS Genet, 2013. PMID 23468645, Free PMC Article
  3. Reduction in Toxicity of Nano-Ag-Polyvinyl-pyrrolidone Using Hydra Proteins and Peptides during Zebrafish Embryogenesis. Kim SS, et al. Nanomaterials (Basel), 2019 Aug 27. PMID 31462001, Free PMC Article
  4. The gsdf gene locus harbors evolutionary conserved and clustered genes preferentially expressed in fish previtellogenic oocytes. Gautier A, et al. Gene, 2011 Feb 1. PMID 21047546
  5. Optimal combination of anti-inflammatory components from Chinese medicinal formula Liang-Ge-San. Lu Z, et al. J Ethnopharmacol, 2021 Apr 6. PMID 33359185

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC123234

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within enteric nervous system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within enteric nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase 10
Names
jnk3
NP_001032790.1
NP_001305247.1
NP_001305248.1
NP_001305250.1
XP_005161528.1
XP_005161530.1
XP_005161531.1
XP_009293442.1
XP_009293445.1
XP_017208303.1
XP_017208304.1
XP_017208305.1
XP_017208306.1
XP_021324567.1
XP_021324568.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037701.2 → NP_001032790.1  mitogen-activated protein kinase 10 isoform 2

    See identical proteins and their annotated locations for NP_001032790.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon, which causes a frameshift compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC109420, BC139642, EH577174, EH579484
    UniProtKB/TrEMBL
    A0A8M1N8E9, A4QP40, Q32LV0
    Related
    ENSDARP00000139912.1, ENSDART00000162834.2
    Conserved Domains (2) summary
    smart00220
    Location:64 → 359
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:63 → 406
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  2. NM_001318318.1 → NP_001305247.1  mitogen-activated protein kinase 10 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (1).
    Source sequence(s)
    BC109420, BC139642, EH577174, EH579484
    UniProtKB/TrEMBL
    A0A0R4IKK9, A0A8M1P821, A4QP40
    Related
    ENSDARP00000134326.2, ENSDART00000160711.2
    Conserved Domains (2) summary
    smart00220
    Location:64 → 359
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:63 → 406
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  3. NM_001318319.1 → NP_001305248.1  mitogen-activated protein kinase 10 isoform 1x

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    BC109420, BC139642, EH577174, EH579484
    UniProtKB/TrEMBL
    A0A8M1P270
    Conserved Domains (2) summary
    smart00220
    Location:64 → 359
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:63 → 406
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  4. NM_001318321.1 → NP_001305250.1  mitogen-activated protein kinase 10 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate acceptor splice site in the 5' region (which results in translation initiation from an in-frame, downstream start codon), lacks an in-frame coding exon, and uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. The resulting isoform (3) has a shorter N-terminus, lacks an 8 aa internal protein segment, and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC109420, BC139642, EH577174, EH579484
    UniProtKB/TrEMBL
    A0A0R4I9H8, A0A8M1P8D2, A4QP40
    Related
    ENSDARP00000129891.1, ENSDART00000159899.2
    Conserved Domains (2) summary
    smart00220
    Location:26 → 321
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    9576133..9717404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009295167.3 → XP_009293442.1  mitogen-activated protein kinase 10 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AWM8
    Conserved Domains (2) summary
    smart00220
    Location:67 → 362
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:66 → 409
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  2. XM_005161471.4 → XP_005161528.1  mitogen-activated protein kinase 10 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B8D5
    Conserved Domains (2) summary
    smart00220
    Location:67 → 362
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:66 → 409
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  3. XM_005161473.4 → XP_005161530.1  mitogen-activated protein kinase 10 isoform X4

    UniProtKB/TrEMBL
    A0A8M2B8C2, A4QP40
    Conserved Domains (2) summary
    smart00220
    Location:67 → 362
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:66 → 401
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  4. XM_021468892.1 → XP_021324567.1  mitogen-activated protein kinase 10 isoform X5

    UniProtKB/TrEMBL
    A0A8M9P3E5, A4QP40
    Conserved Domains (1) summary
    cd07850
    Location:66 → 409
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  5. XM_017352816.2 → XP_017208305.1  mitogen-activated protein kinase 10 isoform X6

    UniProtKB/TrEMBL
    A0A8M6Z3P4, A4QP40
    Conserved Domains (2) summary
    smart00220
    Location:26 → 321
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:25 → 368
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  6. XM_017352817.2 → XP_017208306.1  mitogen-activated protein kinase 10 isoform X8

    UniProtKB/TrEMBL
    A0A8M6YUI1, A4QP40
    Conserved Domains (1) summary
    cd07850
    Location:66 → 409
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  7. XM_017352814.2 → XP_017208303.1  mitogen-activated protein kinase 10 isoform X3

    UniProtKB/TrEMBL
    A0A8M6YV43, A4QP40

  8. XM_005161474.4 → XP_005161531.1  mitogen-activated protein kinase 10 isoform X7

    UniProtKB/TrEMBL
    A0A0R4IB91, A0A8M2B8F3, A4QP40
    Related
    ENSDARP00000131673.1, ENSDART00000161289.2
    Conserved Domains (1) summary
    cd07850
    Location:66 → 409
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  9. XM_009295170.3 → XP_009293445.1  mitogen-activated protein kinase 10 isoform X8

    UniProtKB/TrEMBL
    A0A8M6YUI1, A4QP40
    Conserved Domains (1) summary
    cd07850
    Location:66 → 409
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  10. XM_021468893.1 → XP_021324568.1  mitogen-activated protein kinase 10 isoform X9

    UniProtKB/TrEMBL
    A0A8M9PCS4, A4QP40
    Conserved Domains (1) summary
    cd07850
    Location:66 → 401
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  11. XM_017352815.2 → XP_017208304.1  mitogen-activated protein kinase 10 isoform X6

    UniProtKB/TrEMBL
    A0A8M6Z3P4, A4QP40
    Conserved Domains (2) summary
    smart00220
    Location:26 → 321
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:25 → 368
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
Nucleotide Protein Strain
Heading Accession and Version

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