irak1 interleukin-1 receptor-associated kinase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: irak1provided by ZNC
Official Full Name: interleukin-1 receptor-associated kinase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-071116-5
See related: Ensembl:ENSDARG00000025949 AllianceGenome:ZFIN:ZDB-GENE-071116-5
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in interleukin-1-mediated signaling pathway; intracellular signal transduction; and positive regulation of NF-kappaB transcription factor activity. Predicted to act upstream of or within protein phosphorylation and signal transduction. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in ankylosing spondylitis; diffuse scleroderma; psoriatic arthritis; and squamous cell carcinoma. Orthologous to human IRAK1 (interleukin 1 receptor associated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (7569279..7603707, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (7551150..7584969, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

fd22g09.y1 (e-PCR)
- UniSTS:195294

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Toll signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-1-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NF-kappaB transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of response to stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-1 receptor-associated kinase 1

XP_005166760.1

EC 2.7.1.-

XP_697688.5

EC 2.7.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

7569279..7603707 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005166703.4 → XP_005166760.1 interleukin-1 receptor-associated kinase 1 isoform X1

UniProtKB/TrEMBL

A0A8M2BE72, F6NJE2

Related

ENSDARP00000118154.2, ENSDART00000137975.4

Conserved Domains (3) summary

pfam00069
Location:183 → 446

Pkinase; Protein kinase domain

cl14633
Location:11 → 92

DD; Death Domain Superfamily of protein-protein interaction domains

cl21453
Location:185 → 483

PKc_like; Protein Kinases, catalytic domain
XM_692596.9 → XP_697688.5 interleukin-1 receptor-associated kinase 1 isoform X2

UniProtKB/TrEMBL

A0A8N7TBU9

Conserved Domains (1) summary

cl21453
Location:25 → 275

PKc_like; Protein Kinases, catalytic domain