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PSMB2 proteasome 20S subunit beta 2 [ Homo sapiens (human) ]

Gene ID: 5690, updated on 5-Jan-2025

Summary

Official Symbol
PSMB2provided by HGNC
Official Full Name
proteasome 20S subunit beta 2provided by HGNC
Primary source
HGNC:HGNC:9539
See related
Ensembl:ENSG00000126067 MIM:602175; AllianceGenome:HGNC:9539
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HC7-I
Summary
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in placenta (RPKM 11.8), lymph node (RPKM 10.8) and 25 other tissues See more
Orthologs
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Genomic context

See PSMB2 in Genome Data Viewer
Location:
1p34.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (35599541..35641526, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (35462557..35504550, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (36065142..36107127, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36023162-36023888 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 643 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:36024616-36025341 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36025798-36026432 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:36035818-36035919 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:36038879-36039378 Neighboring gene TFAP2E antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36039620-36040366 Neighboring gene neurochondrin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36042064-36042916 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36042917-36043769 Neighboring gene transcription factor AP-2 epsilon Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:36055869-36056370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:36056371-36056870 Neighboring gene Sharpr-MPRA regulatory region 1763 Neighboring gene MPRA-validated peak173 silencer Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr1:36106102-36107067 and GRCh37_chr1:36107068-36108032 Neighboring gene uncharacterized LOC105378646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:36156281-36156798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:36156799-36157314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 644 Neighboring gene Sharpr-MPRA regulatory region 7840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 645 Neighboring gene chromosome 1 open reading frame 216

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat slightly enhances the activity of the purified 26 S proteasome PubMed
tat Amino acids Lys51, Arg52, and Asp67 of HIV-1 Tat represent the proteasome binding site of Tat, and Tat amino acids 37-72 are necessary for proteasomal interaction and suppression of 11 S regulator-mediated antigen presentation PubMed
tat HIV-1 Tat inhibits the peptidase activity of the 20 S proteasome and interferes with the formation of the 20 S proteasome-11 S regulator complex PubMed
tat HIV-1 Tat binds to the alpha2, alpha4, alpha6, alpha7, beta1, beta2, beta3, beta5, beta6, beta7, LMP7/beta5i, and MECL1/beta2i subunits of the proteasome 20 S core structure and can inhibit cellular proteasome function PubMed
Vif vif HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication PubMed
integrase gag-pol Proteasomal degradation of HIV-1 integrase in mammalian cells occurs by the N-end rule pathway PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC104215, MGC126885

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in cytoplasm PubMed 
is_active_in cytosol  
located_in cytosol  
located_in extracellular exosome PubMed 
located_in membrane PubMed 
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus PubMed 
is_active_in nucleus  
is_active_in nucleus PubMed 
part_of proteasome complex PubMed 
part_of proteasome complex PubMed 
part_of proteasome core complex PubMed 
part_of proteasome core complex  
part_of proteasome core complex, beta-subunit complex  
part_of proteasome core complex, beta-subunit complex  

General protein information

Preferred Names
proteasome subunit beta type-2
Names
beta-4
macropain subunit C7-I
multicatalytic endopeptidase complex subunit C7-1
multicatalytic endopeptidase complex subunit C7-I
proteasome (prosome, macropain) subunit, beta type, 2
proteasome beta 2 subunit
proteasome component C7-I
proteasome subunit beta 2
proteasome subunit beta-4
proteasome subunit beta4
proteasome subunit, beta type, 2
testicular tissue protein Li 152
NP_001186708.1
NP_001186709.1
NP_002785.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199779.2NP_001186708.1  proteasome subunit beta type-2 isoform 2

    See identical proteins and their annotated locations for NP_001186708.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the 5' region, as compared to variant 1. The resulting isoform (2) lacks an internal segment in the N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK296956, AL157951, BM664618
    UniProtKB/TrEMBL
    B7Z478
    Conserved Domains (1) summary
    cd03758
    Location:6167
    proteasome_beta_type_2; proteasome beta type-2 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
  2. NM_001199780.2NP_001186709.1  proteasome subunit beta type-2 isoform 3

    See identical proteins and their annotated locations for NP_001186709.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two exons from the 5' end and has an alternate 5' exon, as compared to variant 1. The resulting isoform (3) is shorter at the N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK310023, AL157951, BM664618
    Consensus CDS
    CCDS72755.1
    UniProtKB/TrEMBL
    A0A087WVV1
    Related
    ENSP00000479706.1, ENST00000621781.4
    Conserved Domains (1) summary
    cl00467
    Location:175
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  3. NM_002794.5NP_002785.1  proteasome subunit beta type-2 isoform 1

    See identical proteins and their annotated locations for NP_002785.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL157951, AL354864, BC101836, BM664618
    Consensus CDS
    CCDS394.1
    UniProtKB/Swiss-Prot
    D3DPS0, P31145, P49721, Q9BWZ9
    UniProtKB/TrEMBL
    A0A140VJS6
    Related
    ENSP00000362334.3, ENST00000373237.4
    Conserved Domains (1) summary
    cd03758
    Location:1192
    proteasome_beta_type_2; proteasome beta type-2 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    35599541..35641526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    35462557..35504550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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