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Rbms1 RNA binding motif, single stranded interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 56878, updated on 21-Apr-2024

Summary

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Official Symbol
Rbms1provided by MGI
Official Full Name
RNA binding motif, single stranded interacting protein 1provided by MGI
Primary source
MGI:MGI:1861774
See related
Ensembl:ENSMUSG00000026970 AllianceGenome:MGI:1861774
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
YC1; MSSP-1; MSSP-2; MSSP-3; 2600014B10Rik
Summary
Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Predicted to act upstream of or within DNA replication. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and immune system. Orthologous to human RBMS1 (RNA binding motif single stranded interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 26.0), ovary adult (RPKM 17.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 C1.2; 2 34.95 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (60580537..60794224, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (60750193..60963880, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S21 pseudogene Neighboring gene integrin beta 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:60555461-60555644 Neighboring gene STARR-seq mESC enhancer starr_04618 Neighboring gene predicted gene, 33436 Neighboring gene VISTA enhancer mm1564 Neighboring gene STARR-seq mESC enhancer starr_04621 Neighboring gene STARR-seq mESC enhancer starr_04622 Neighboring gene STARR-positive B cell enhancer ABC_E9002 Neighboring gene STARR-positive B cell enhancer ABC_E5923 Neighboring gene predicted gene, 50617 Neighboring gene predicted gene 13582 Neighboring gene predicted gene, 33647 Neighboring gene predicted gene, 39833

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RNA Binding Protein Rbms1 Enables Neuronal Differentiation and Radial Migration during Neocortical Development by Binding and Stabilizing the RNA Message for Efr3a. Habib K, et al. Mol Cells, 2022 Aug 31. PMID 35754370, Free PMC Article
  2. Positive regulation of Fas gene expression by MSSP and abrogation of Fas-mediated apoptosis induction in MSSP-deficient mice. Nomura J, et al. Exp Cell Res, 2005 May 1. PMID 15817157
  3. Disruption of MSSP, c-myc single-strand binding protein, leads to embryonic lethality in some homozygous mice. Fujimoto M, et al. Genes Cells, 2001 Dec. PMID 11737267
  4. Structures and comparison of genomic and complementary DNAs of mouse MSSP, a c-Myc binding protein. Fujimoto M, et al. Int J Oncol, 2000 Feb. PMID 10639566
  5. Transactivation of microRNA-383 by steroidogenic factor-1 promotes estradiol release from mouse ovarian granulosa cells by targeting RBMS1. Yin M, et al. Mol Endocrinol, 2012 Jul. PMID 22593182, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircRbms1 fosters MST1 mRNA and protein levels to motivate myocardial ischaemia-reperfusion injury via autophagic status.
    Title: CircRbms1 fosters MST1 mRNA and protein levels to motivate myocardial ischaemia-reperfusion injury via autophagic status.
  2. Transcriptomic and Proteomic Analysis Reveals the Potential Role of RBMS1 in Adipogenesis and Adipocyte Metabolism.
    Title: Transcriptomic and Proteomic Analysis Reveals the Potential Role of RBMS1 in Adipogenesis and Adipocyte Metabolism.
  3. study demonstrates that miR-383 functions as a positive regulator of E2 release in ovarian granulosa cells through inhibiting expression of RBMS1 and its downstream c-Myc
    Title: Transactivation of microRNA-383 by steroidogenic factor-1 promotes estradiol release from mouse ovarian granulosa cells by targeting RBMS1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(U) RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding motif, single-stranded-interacting protein 1
Names
single-stranded DNA-binding protein MSSP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001141931.1 → NP_001135403.1  RNA-binding motif, single-stranded-interacting protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) has a shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AA175245, AK145897, AK147109, AK161102
    UniProtKB/TrEMBL
    Q3UKR8, Q3V0L4
    Conserved Domains (2) summary
    cd12470
    Location:53 → 138
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:139 → 224
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

  2. NM_001141932.1 → NP_001135404.1  RNA-binding motif, single-stranded-interacting protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA175245, AK145897, AK161102
    Consensus CDS
    CCDS50590.1
    UniProtKB/TrEMBL
    E9PZ21, Q3TTX8
    Related
    ENSMUSP00000131306.2, ENSMUST00000164147.8
    Conserved Domains (2) summary
    cd12470
    Location:53 → 138
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:139 → 224
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

  3. NM_020296.2 → NP_064692.2  RNA-binding motif, single-stranded-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_064692.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a different 5' UTR and 5' coding region and lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded protein (isoform 3) has a distinct N-terminus and a shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AA175245, AK147109, AK161102, BC016501
    Consensus CDS
    CCDS50591.1
    UniProtKB/Swiss-Prot
    Q3UI25, Q3UXU2, Q6PEU6, Q6PHC2, Q91W59, Q9WTK4
    UniProtKB/TrEMBL
    Q3UKR8, Q3V0L4
    Related
    ENSMUSP00000028347.7, ENSMUST00000028347.13
    Conserved Domains (2) summary
    cd12470
    Location:55 → 140
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:141 → 226
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    60580537..60794224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499940.2 → XP_006500003.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    Q3TTX8
    Conserved Domains (2) summary
    cd12470
    Location:55 → 140
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:141 → 226
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

  2. XM_030251908.1 → XP_030107768.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X6

    UniProtKB/TrEMBL
    Q3UKR8, Q3V0L4
    Conserved Domains (2) summary
    cd12470
    Location:55 → 140
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:141 → 226
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

  3. XM_017319146.1 → XP_017174635.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X3

    UniProtKB/TrEMBL
    Q3TTX8
    Conserved Domains (2) summary
    cd12470
    Location:55 → 140
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:141 → 226
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

  4. XM_030251910.1 → XP_030107770.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X8

    UniProtKB/TrEMBL
    Q3UKR8, Q3V0L4
    Conserved Domains (2) summary
    cd12470
    Location:35 → 120
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:121 → 206
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

  5. XM_006499942.3 → XP_006500005.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X5

    UniProtKB/TrEMBL
    Q3TTX8
    Conserved Domains (2) summary
    cd12470
    Location:35 → 120
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:121 → 206
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

  6. XM_030251909.2 → XP_030107769.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X7

    UniProtKB/TrEMBL
    Q3UKR8, Q3V0L4
    Conserved Domains (2) summary
    cd12470
    Location:53 → 138
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:139 → 224
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

  7. XM_030251907.2 → XP_030107767.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X4

    UniProtKB/TrEMBL
    Q3TTX8
    Conserved Domains (2) summary
    cd12470
    Location:53 → 138
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:139 → 224
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

  8. XM_036162420.1 → XP_036018313.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X2

    UniProtKB/TrEMBL
    Q3TTX8
    Conserved Domains (2) summary
    cd12470
    Location:45 → 130
    RRM1_MSSP1; RNA recognition motif 1 (RRM1) found in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12473
    Location:131 → 215
    RRM2_MSSP1; RNA recognition motif 2 (RRM2) found in vertebrate single-stranded DNA-binding protein MSSP-1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91W59.1 GenPept UniProtKB/Swiss-Prot:Q91W59

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