U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

lrp5 low density lipoprotein receptor-related protein 5 [ Danio rerio (zebrafish) ]

Gene ID: 568518, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
lrp5provided by ZNC
Official Full Name
low density lipoprotein receptor-related protein 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-050518-2
See related
Ensembl:ENSDARG00000006921 AllianceGenome:ZFIN:ZDB-GENE-050518-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
LRP6
Summary
Acts upstream of or within animal organ development; canonical Wnt signaling pathway; and sensory perception of sound. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including brain; head; pectoral fin bud; posterior lateral line primordium; and tail bud. Used to study nonsyndromic deafness. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; bone remodeling disease (multiple); eye disease (multiple); osteoporosis-pseudoglioma syndrome; and polycystic liver disease. Orthologous to human LRP5 (LDL receptor related protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 25
Exon count:
24
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (10645644..10768821, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (10549084..10672033, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene si:ch211-107e6.5 Neighboring gene si:ch211-107e6.6 Neighboring gene protein phosphatase 6, regulatory subunit 3 Neighboring gene wu:fa25f02 Neighboring gene adaptor related protein complex 3 subunit sigma 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Lrp5 Mutant and Crispant Zebrafish Faithfully Model Human Osteoporosis, Establishing the Zebrafish as a Platform for CRISPR-Based Functional Screening of Osteoporosis Candidate Genes. Bek JW, et al. J Bone Miner Res, 2021 Sep. PMID 33957005
  2. New role of LRP5, associated with nonsyndromic autosomal-recessive hereditary hearing loss. Xia W, et al. Hum Mutat, 2017 Oct. PMID 28677207
  3. A genome-wide survey demonstrates widespread non-linear mRNA in expressed sequences from multiple species. Dixon RJ, et al. Nucleic Acids Res, 2005. PMID 16237125, Free PMC Article
  4. Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation. Khrystoforova I, et al. Front Endocrinol (Lausanne), 2022. PMID 36120446, Free PMC Article
  5. The Wnt Co-Receptor Lrp5 Is Required for Cranial Neural Crest Cell Migration in Zebrafish. Willems B, et al. PLoS One, 2015. PMID 26121341, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation.
    Title: Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation.
  2. Rescue experiments showed that LRP5 mutation is associated with hearing loss. Knocking down lrp5 in zebrafish results in reduced expression of several genes linked to Wnt signaling pathway and decreased cell proliferation when compared with those in wild-type zebrafish
    Title: New role of LRP5, associated with nonsyndromic autosomal-recessive hereditary hearing loss.
  3. Data show that in zebrafish, lrp5 also controls cell migration during early morphogenetic processes and contributes to shaping the craniofacial skeleton.
    Title: The Wnt Co-Receptor Lrp5 Is Required for Cranial Neural Crest Cell Migration in Zebrafish.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables Wnt receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anterior lateral line neuromast hair cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within bone mineralization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cartilage development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fin regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within liver development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within otolith morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within posterior lateral line neuromast hair cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
low-density lipoprotein receptor-related protein 5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177458.1 → NP_001170929.1  low-density lipoprotein receptor-related protein 5

    See identical proteins and their annotated locations for NP_001170929.1

    Status: PROVISIONAL

    Source sequence(s)
    GQ903573
    UniProtKB/TrEMBL
    D0EWS1
    Related
    ENSDARP00000149886.1, ENSDART00000184490.1
    Conserved Domains (4) summary
    smart00135
    Location:271 → 314
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:1115 → 1149
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:205 → 244
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:425 → 460
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    10645644..10768821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009297823.3 → XP_009296098.1  low-density lipoprotein receptor-related protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A8M3APK3, F1QTJ4
    Related
    ENSDARP00000108864.1, ENSDART00000121724.4
    Conserved Domains (4) summary
    smart00135
    Location:456 → 499
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:1300 → 1334
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:168 → 208
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:610 → 645
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_009297824.3 → XP_009296099.1  low-density lipoprotein receptor-related protein 5 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AZI2
    Conserved Domains (4) summary
    smart00135
    Location:456 → 499
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:1300 → 1334
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:168 → 208
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:610 → 645
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous