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Haao 3-hydroxyanthranilate 3,4-dioxygenase [ Rattus norvegicus (Norway rat) ]

Gene ID: 56823, updated on 11-Apr-2024

Summary

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Official Symbol
Haaoprovided by RGD
Official Full Name
3-hydroxyanthranilate 3,4-dioxygenaseprovided by RGD
Primary source
RGD:71071
See related
Ensembl:ENSRNOG00000031263 AllianceGenome:RGD:71071
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables 3-hydroxyanthranilate 3,4-dioxygenase activity; iron ion binding activity; and oxygen binding activity. Involved in quinolinate metabolic process. Located in mitochondrial membrane. Used to study Huntington's disease. Orthologous to human HAAO (3-hydroxyanthranilate 3,4-dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 501.5) and Kidney (RPKM 370.3) See more
Orthologs
human mouse all
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Genomic context

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Location:
6q12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (16598325..16617590)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (10845235..10864863)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (7045145..7059227, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548368 Neighboring gene wiskott-Aldrich syndrome protein family member 1-like Neighboring gene transfer RNA isoleucine (anticodon UAU) 2 Neighboring gene uncharacterized LOC120093196 Neighboring gene metastasis associated 1 family, member 3 Neighboring gene uncharacterized LOC134479096

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Immunohistochemical visualization of newly formed quinolinate in the normal and excitotoxically lesioned rat striatum. Lehrmann E, et al. Exp Brain Res, 2001 Dec. PMID 11715084
  2. Effects of oxygen on 3-hydroxyanthranilate oxidase of the kynurenine pathway. Dang Y, et al. Free Radic Biol Med, 1998 Dec. PMID 9870556
  3. Increase in the level of mRNA for 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice. Nakagawa Y, et al. Biosci Biotechnol Biochem, 1995 Nov. PMID 8541664
  4. Rat 3-hydroxyanthranilic acid oxygenase: purification from the liver and immunocytochemical localization in the brain. Okuno E, et al. J Neurochem, 1987 Sep. PMID 3112306
  5. Synthesis of quinolinic acid by 3-hydroxyanthranilic acid oxygenase in rat brain tissue in vitro. Foster AC, et al. J Neurochem, 1986 Jul. PMID 2940338

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-hydroxyanthranilate 3,4-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-hydroxyanthranilate 3,4-dioxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-hydroxyanthranilate 3,4-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3-hydroxyanthranilate 3,4-dioxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables ferrous iron binding IEA
Inferred from Electronic Annotation
more info
  
enables ferrous iron binding ISO
Inferred from Sequence Orthology
more info
  
enables iron ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxygen binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' NAD biosynthetic process from tryptophan IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' NAD biosynthetic process from tryptophan IEA
Inferred from Electronic Annotation
more info
  
involved_in NAD biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in anthranilate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron cellular homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron cellular homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in quinolinate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in quinolinate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in quinolinate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in quinolinate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to cadmium ion IEA
Inferred from Electronic Annotation
more info
  
involved_in response to cadmium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in response to zinc ion IEA
Inferred from Electronic Annotation
more info
  
involved_in response to zinc ion ISO
Inferred from Sequence Orthology
more info
  
involved_in tryptophan catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
3-hydroxyanthranilate 3,4-dioxygenase
Names
3-HAO
3-hydroxyanthranilate oxygenase
3-hydroxyanthranilic acid dioxygenase
HAD
NP_064461.1
XP_038968722.1
XP_063118443.1
XP_063118444.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020076.2 → NP_064461.1  3-hydroxyanthranilate 3,4-dioxygenase

    See identical proteins and their annotated locations for NP_064461.1

    Status: PROVISIONAL

    Source sequence(s)
    D44494
    UniProtKB/Swiss-Prot
    P46953, P70474, Q5RKK0, Q64556
    UniProtKB/TrEMBL
    A0A0G2JSV5
    Related
    ENSRNOP00000043835.2, ENSRNOT00000045996.3
    Conserved Domains (1) summary
    cl21464
    Location:2 → 149
    cupin_like; Conserved domain found in cupin and related proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    16598325..16617590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112794.2 → XP_038968722.1  3-hydroxyanthranilate 3,4-dioxygenase isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZR59, A0A8I6GEE8
    Related
    ENSRNOP00000085878.1
    Conserved Domains (2) summary
    cd06123
    Location:10 → 159
    cupin_HAO; 3-Hydroxyanthranilate-3,4-dioxygenase, cupin domain
    cl40423
    Location:209 → 259
    cupin_RmlC-like; RmlC-like cupin superfamily

  2. XM_063262374.1 → XP_063118444.1  3-hydroxyanthranilate 3,4-dioxygenase isoform X3

  3. XM_063262373.1 → XP_063118443.1  3-hydroxyanthranilate 3,4-dioxygenase isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46953.2 GenPept UniProtKB/Swiss-Prot:P46953

Gene LinkOut

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