wwtr1 WW domain containing transcription regulator 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wwtr1provided by ZNC
Official Full Name: WW domain containing transcription regulator 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-051101-1
See related: Ensembl:ENSDARG00000067719 AllianceGenome:ZFIN:ZDB-GENE-051101-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable transcription coactivator activity and transcription corepressor activity. Involved in regulation of gene expression. Acts upstream of with a positive effect on BMP signaling pathway. Acts upstream of or within several processes, including animal organ development; epithelial cell differentiation; and negative regulation of retinoic acid receptor signaling pathway. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; digestive system; endocrine system; head; and mesoderm. Orthologous to human WWTR1 (WW domain containing transcription regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (38048943..38120728)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (38095543..38161984)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings uncover a novel mode of lateral inhibition in cell fate specification based on mechanical signals controlling TAZ activity.
Title: Lateral Inhibition in Cell Specification Mediated by Mechanical Signals Modulating TAZ Activity.
Study in zebrafish fluorescent transgenic reporter lines of Yap1/Taz provided an in vivo view of Yap1/Taz activity during development and adulthood at the whole organism level. Analysis of vascular development in yap1/taz zebrafish mutants revealed specific defects in posterior cardinal vein formation, with altered expression of arterial/venous markers.
Title: Zebrafish mutants and TEAD reporters reveal essential functions for Yap and Taz in posterior cardinal vein development.
Taz is essential for micropylar cell fate acquisition and subsequent micropyle formation in zebrafish.
Title: The Hippo pathway effector Taz is required for cell morphogenesis and fertilization in zebrafish.
ur work identifies a novel role for the Hippo/Taz pathway in micropylar cell specification in zebrafish, and uncovers the molecular basis of micropyle formation in teleosts.
Title: The effector of Hippo signaling, Taz, is required for formation of the micropyle and fertilization in zebrafish.
The authors show that the Hippo pathway transcriptional coactivators Yap1 and Wwtr1 are specifically localized to the presumptive epidermis and notochord, and play a critical and unexpected role in posterior body extension by regulating Fibronectin assembly underneath the presumptive epidermis and surrounding the notochord.
Title: Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1.
Altogether, the data suggest that Wwtr1 establishes the compact wall architecture necessary for trabeculation, and that Nrg/Erbb2 signaling negatively regulates its nuclear localization and therefore its activity.
Title: The Hippo pathway effector Wwtr1 regulates cardiac wall maturation in zebrafish.
Yap/Taz-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.
Title: Yap and Taz regulate retinal pigment epithelial cell fate.
Taz-depleted larvae displayed patterning defects in ventral cranial vessels that correlate with lateral displacement of thyroid follicles
Title: Thyroid development in zebrafish lacking Taz.
Taz is required in the anteroposterior patterning of the pronephric progenitor domain in the intermediate mesoderm, acting in part by regulating retinoic acid signaling in the pronephric progenitor field in the intermediate mesoderm.
Title: The transcriptional coactivator Taz regulates proximodistal patterning of the pronephric tubule in zebrafish.
When transcriptional coactivators Yap and Taz were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.
Title: Establishment of transgenic lines to monitor and manipulate Yap/Taz-Tead activity in zebrafish reveals both evolutionarily conserved and divergent functions of the Hippo pathway.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_positive_effect BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_positive_effect BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Kupffer's vesicle development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within anterior/posterior pattern specification involved in pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chorion micropyle formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within determination of heart left/right asymmetry	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within determination of heart left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of fibronectin fibril organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of fibronectin fibril organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of retinoic acid receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinal pigment epithelium development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculature development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular trabecula myocardium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WW domain-containing transcription regulator protein 1

Names: taz

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037696.1 → NP_001032785.1 WW domain-containing transcription regulator protein 1

See identical proteins and their annotated locations for NP_001032785.1

Status: PROVISIONAL

Source sequence(s)

DQ238862

UniProtKB/TrEMBL

B3DGC6, Q307I6

Related

ENSDARP00000088304.4, ENSDART00000097533.6

Conserved Domains (1) summary

smart00456
Location:115 → 146

WW; Domain with 2 conserved Trp (W) residues

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007133.7 Reference GRCz11 Primary Assembly

Range

38048943..38120728

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005161848.4 → XP_005161905.1 WW domain-containing transcription regulator protein 1 isoform X1

UniProtKB/TrEMBL

A0A8M2B8N9

Conserved Domains (1) summary

smart00456
Location:115 → 146

WW; Domain with 2 conserved Trp (W) residues