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alox5a arachidonate 5-lipoxygenase a [ Danio rerio (zebrafish) ]

Gene ID: 567204, updated on 11-Apr-2024

Summary

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Official Symbol
alox5aprovided by ZNC
Official Full Name
arachidonate 5-lipoxygenase aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-090311-47
See related
Ensembl:ENSDARG00000057273 AllianceGenome:ZFIN:ZDB-GENE-090311-47
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
alox5; si:dkey-194n13.2
Summary
Enables arachidonate 5-lipoxygenase activity; arachidonic acid monooxygenase activity; and leukotriene-C4 synthase activity. Acts upstream of or within arachidonic acid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in nuclear envelope. Is expressed in pronephric duct. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 13
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (18127662..18174864, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (17996670..18043872, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene zinc finger, AN1-type domain 4 Neighboring gene WASH complex subunit 2C Neighboring gene solute carrier family 25 member 16 Neighboring gene tet methylcytosine dioxygenase 1 Neighboring gene uncharacterized LOC110440176

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Stereocontrol of arachidonic acid oxygenation by vertebrate lipoxygenases: newly cloned zebrafish lipoxygenase 1 does not follow the Ala-versus-Gly concept. Jansen C, et al. J Biol Chem, 2011 Oct 28. PMID 21880725, Free PMC Article
  2. Lipid peroxidation regulates long-range wound detection through 5-lipoxygenase in zebrafish. Katikaneni A, et al. Nat Cell Biol, 2020 Sep. PMID 32868902, Free PMC Article
  3. Biochemical characterization of three BLT receptors in zebrafish. Okuno T, et al. PLoS One, 2015. PMID 25738285, Free PMC Article
  4. Phosphorylation mimicking mutations of ALOX5 orthologs of different vertebrates do not alter reaction specificities of the enzymes. Adel S, et al. Biochim Biophys Acta, 2014 Oct. PMID 25025884
  5. Neutrophil Swarming in Damaged Tissue Is Orchestrated by Connexins and Cooperative Calcium Alarm Signals. Poplimont H, et al. Curr Biol, 2020 Jul 20. PMID 32502410, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables arachidonate 5-lipoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arachidonate 5-lipoxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables arachidonate 5-lipoxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables arachidonic acid monooxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables leukotriene-C4 synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in arachidonic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within arachidonic acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within inflammatory response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in lipoxygenase pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
polyunsaturated fatty acid 5-lipoxygenase
Names
ALOX2
LOX2
NP_001290191.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303262.1 → NP_001290191.1  polyunsaturated fatty acid 5-lipoxygenase

    Status: VALIDATED

    Source sequence(s)
    BX927098, CU012047
    UniProtKB/TrEMBL
    A0A8M1P6P6, B8A697
    Related
    ENSDARP00000074335.5, ENSDART00000079884.6
    Conserved Domains (2) summary
    cd01753
    Location:2 → 115
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:227 → 665
    Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    18127662..18174864 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394875.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    92472..135626 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001256747.1: Suppressed sequence

    Description
    NM_001256747.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version

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