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bub1bb BUB1 mitotic checkpoint serine/threonine kinase Bb [ Danio rerio (zebrafish) ]

Gene ID: 567006, updated on 11-Apr-2024

Summary

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Official Symbol
bub1bbprovided by ZNC
Official Full Name
BUB1 mitotic checkpoint serine/threonine kinase Bbprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030829-51
See related
Ensembl:ENSDARG00000074927 AllianceGenome:ZFIN:ZDB-GENE-030829-51
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sb:cb730
Summary
Predicted to enable protein kinase activity. Predicted to be involved in meiotic sister chromatid cohesion, centromeric and mitotic spindle assembly checkpoint signaling. Is expressed in hindbrain; optic tectum; pectoral fin musculature; proliferative region; and retina. Human ortholog(s) of this gene implicated in colorectal cancer and mosaic variegated aneuploidy syndrome 1. Orthologous to human BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See bub1bb in Genome Data Viewer
Location:
chromosome: 17
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (2127013..2148106)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (1950200..1971293)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14D Neighboring gene zinc finger, FYVE domain containing 19 Neighboring gene serine/threonine-protein kinase PAK 6 Neighboring gene ankyrin repeat domain 63

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. High-throughput genome editing and phenotyping facilitated by high resolution melting curve analysis. Thomas HR, et al. PLoS One, 2014. PMID 25503746, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Names
budding uninhibited by benzimidazoles 1 homolog beta b
XP_695384.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    2127013..2148106
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_690292.8 → XP_695384.3  mitotic checkpoint serine/threonine-protein kinase BUB1 beta

    UniProtKB/TrEMBL
    A0A8N7T876, E7F5T9
    Related
    ENSDARP00000099195.2, ENSDART00000110529.4
    Conserved Domains (1) summary
    pfam08311
    Location:45 → 165
    Mad3_BUB1_I; Mad3/BUB1 homology region 1
Nucleotide Protein Strain
Heading Accession and Version

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