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mcm6 minichromosome maintenance complex component 6 [ Danio rerio (zebrafish) ]

Gene ID: 566409, updated on 27-Mar-2024

Summary

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Official Symbol
mcm6provided by ZNC
Official Full Name
minichromosome maintenance complex component 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-030909-6
See related
Ensembl:ENSDARG00000057683 AllianceGenome:ZFIN:ZDB-GENE-030909-6
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
MCM6z; cb800; im:7140796; wu:fb30d05; wu:fc26f09
Summary
Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded 3'-5' DNA helicase activity. Predicted to be involved in DNA unwinding involved in DNA replication; double-strand break repair via break-induced replication; and mitotic DNA replication. Predicted to act upstream of or within DNA duplex unwinding and DNA replication initiation. Predicted to be part of MCM complex. Predicted to be active in nucleus. Is expressed in central nervous system and proliferative region. Orthologous to human MCM6 (minichromosome maintenance complex component 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (12968146..12985390)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (12733288..12750532)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene islet cell autoantigen 1-like Neighboring gene chemokine (C-X-C motif) receptor 4a Neighboring gene si:ch73-71c20.5 Neighboring gene transmembrane BAX inhibitor motif containing 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Deregulation of whole-transcriptome gene expression in zebrafish (Danio rerio) after chronic exposure to low doses of imatinib mesylate in a complete life cycle study. Novak M, et al. Chemosphere, 2021 Jan. PMID 33297093
  2. Cohesin facilitates zygotic genome activation in zebrafish. Meier M, et al. Development, 2018 Jan 3. PMID 29158440
  3. Evolutionary diversification of MCM3 genes in Xenopus laevis and Danio rerio. Shinya M, et al. Cell Cycle, 2014. PMID 25485507, Free PMC Article
  4. DHX33 Transcriptionally Controls Genes Involved in the Cell Cycle. Yuan B, et al. Mol Cell Biol, 2016 Dec 1. PMID 27601587, Free PMC Article
  5. The knockdown of maternal glucocorticoid receptor mRNA alters embryo development in zebrafish. Pikulkaew S, et al. Dev Dyn, 2011 Apr. PMID 21360790

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC158377

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to single-stranded 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MCM complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA replication licensing factor MCM6
Names
MCM6 minichromosome maintenance deficient 6, mitotin
zygotic Mcm6 protein
NP_001076318.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082849.1 → NP_001076318.1  DNA replication licensing factor MCM6

    See identical proteins and their annotated locations for NP_001076318.1

    Status: PROVISIONAL

    Source sequence(s)
    BC133090
    UniProtKB/TrEMBL
    A3KMS0
    Related
    ENSDARP00000022256.8, ENSDART00000013781.9
    Conserved Domains (3) summary
    smart00350
    Location:117 → 655
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:27 → 137
    MCM_N; MCM N-terminal domain
    cl21455
    Location:445 → 532
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    12968146..12985390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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