qdpra quinoid dihydropteridine reductase a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: qdpraprovided by ZNC
Official Full Name: quinoid dihydropteridine reductase aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070705-197
See related: Ensembl:ENSDARG00000040190 AllianceGenome:ZFIN:ZDB-GENE-070705-197
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-89f22.2
Summary: Predicted to enable 6,7-dihydropteridine reductase activity; NADH binding activity; and NADPH binding activity. Acts upstream of or within L-phenylalanine metabolic process and melanin biosynthetic process. Predicted to be active in cytoplasm. Is expressed in eye; liver; melanoblast; and presumptive retinal pigmented epithelium. Human ortholog(s) of this gene implicated in phenylketonuria. Orthologous to human QDPR (quinoid dihydropteridine reductase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (46876360..46897044, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (47889279..47909963, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 6,7-dihydropteridine reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NADH binding	IBA Inferred from Biological aspect of Ancestor more info
enables NADPH binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-phenylalanine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within L-phenylalanine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within melanin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tetrahydrobiopterin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: quinoid dihydropteridine reductase a

Names: dhpra

NP_001103939.1

EC 1.5.1.34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110469.1 → NP_001103939.1 quinoid dihydropteridine reductase a

See identical proteins and their annotated locations for NP_001103939.1

Status: PROVISIONAL

Source sequence(s)

BC115316

UniProtKB/TrEMBL

A0A8M1NGL6, A7YT77

Related

ENSDARP00000058788.5, ENSDART00000058789.7

Conserved Domains (2) summary

cd05334
Location:4 → 226

DHPR_SDR_c_like; dihydropteridine reductase (DHPR), classical (c) SDRs

PRK12828
Location:7 → 222

PRK12828; short chain dehydrogenase; Provisional