Anxa2 annexin A2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Anxa2provided by RGD
Official Full Name: annexin A2provided by RGD
Primary source: RGD:621170
See related: Ensembl:ENSRNOG00000010362 AllianceGenome:RGD:621170
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ANX2
Summary: Enables bone sialoprotein binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and small GTPase binding activity. Involved in several processes, including positive regulation of fibroblast proliferation; protein localization to plasma membrane; and response to thyroid hormone. Located in several cellular components, including macropinosome; membrane raft; and ruffle. Part of protein-containing complex. Biomarker of hyperthyroidism; hypothyroidism; and renal cell carcinoma. Human ortholog(s) of this gene implicated in osteonecrosis. Orthologous to several human genes including ANXA2 (annexin A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 1285.6), Heart (RPKM 657.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (78986252..79022638)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (70105268..70141663)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (75687134..75723589)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

METTL3-mediated ANXA2 inhibition confers neuroprotection in ischemic stroke: Evidence from in vivo and in vitro studies.
Title: METTL3-mediated ANXA2 inhibition confers neuroprotection in ischemic stroke: Evidence from in vivo and in vitro studies.
Annexin A2 degradation contributes to dopaminergic cell apoptosis via regulating p53 in neurodegenerative conditions.
Title: Annexin A2 degradation contributes to dopaminergic cell apoptosis via regulating p53 in neurodegenerative conditions.
ANGII increases Annexin-A2 nucleic acid-binding activity and elevates protein levels of the NFAT5 transcription factor in kidneys of hypertensive rats.
Title: NFAT5 regulates renal gene expression in response to angiotensin II through Annexin-A2-mediated posttranscriptional regulation in hypertensive rats.
The present study found that social isolation during adolescence resulted in abnormal locomotor, emotional and cognitive behaviors and increased the expression of GFAP, ANXA2 and VIM in PFC of adult rats.
Title: Adolescent social isolation affects schizophrenia-like behavior and astrocyte biomarkers in the PFC of adult rats.
Cav-1 participates upstream of ANXA2 in the activation of ERK1/2 and NF-kappaB.
Title: Annexin A2-modulated proliferation of pulmonary arterial smooth muscle cells depends on caveolae and caveolin-1 in hepatopulmonary syndrome.
The results indicate that ANXA2 is critical for the integrity of the blood-testis barrier and the timely release of spermatids.
Title: Annexin A2 is critical for blood-testis barrier integrity and spermatid disengagement in the mammalian testis.
Concordant with the levels of AnxA2, the levels of both LC3 and collagen VI (COL VI) were decreased in the LPS group but not in the LPS + CORM group. Given the established roles of AnxA2 in fibrinolysis as well as intracellular vesicle trafficking, AnxA2 down-regulation should play an important role in the pathogenesis of septic lung injuries.
Title: A CO-releasing molecule prevents annexin A2 down-regulation and associated disorders in LPS-administered rat lung.
Our data suggested that ANXA2 might play important roles in CNS pathophysiology after spinal cord injury.
Title: The upregulation of annexin A2 after spinal cord injury in rats may have implication for astrocyte proliferation.
Oxidative stress causes the incorporation of pTyr23AnxA2 into extracellular vesicles.
Title: Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of annexin A2.
Alterations of Annexin A2 may be involved in tissue-type plasminogen activator-dependent plasticity after peripheral nerve injury and have an important role in neuropathic pain.
Title: Annexin A2 in primary afferents contributes to neuropathic pain associated with tissue type plasminogen activator.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF406531 (e-PCR)
- UniSTS:248385

RH129518 (e-PCR)
- UniSTS:212821

RH143050 (e-PCR)
- UniSTS:232297

RH128604 (e-PCR)
- UniSTS:211912

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables S100 protein binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	TAS Traceable Author Statement more info	PubMed
enables bone sialoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	TAS Traceable Author Statement more info	PubMed
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipid binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A2 inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in body fluid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in collagen fibril organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within collagen fibril organization	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epithelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in fibrinolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fibrinolysis	ISO Inferred from Sequence Orthology more info
involved_in lung development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in mRNA transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in membrane raft assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of low-density lipoprotein particle receptor catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of low-density lipoprotein particle receptor catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in osteoclast development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation by host of viral process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of low-density lipoprotein particle clearance	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of plasminogen activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor recycling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor recycling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor-mediated endocytosis involved in cholesterol transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor-mediated endocytosis involved in cholesterol transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor-mediated endocytosis involved in cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vacuole organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vesicle fusion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of viral life cycle	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of fibrinolysis	TAS Traceable Author Statement more info	PubMed
involved_in regulation of neurogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to activity	ISO Inferred from Sequence Orthology more info
involved_in response to thyroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in vesicle budding from membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of AnxA2-p11 complex	ISO Inferred from Sequence Orthology more info
part_of PCSK9-AnxA2 complex	ISO Inferred from Sequence Orthology more info
part_of RNA polymerase II transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in Schmidt-Lanterman incisure	IEA Inferred from Electronic Annotation more info
located_in Schmidt-Lanterman incisure	ISO Inferred from Sequence Orthology more info
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cornified envelope	IEA Inferred from Electronic Annotation more info
is_active_in cornified envelope	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in exocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in macropinosome	IDA Inferred from Direct Assay more info	PubMed
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in myelin sheath adaxonal region	IEA Inferred from Electronic Annotation more info
located_in myelin sheath adaxonal region	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of plasma membrane protein complex	IEA Inferred from Electronic Annotation more info
part_of plasma membrane protein complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: annexin A2

Names: PAP-IV; annexin-2; calpactin I heavy chain; calpactin-1 heavy chain; chromobindin-8; lipocortin II; p36; placental anticoagulant protein IV; protein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019905.1 → NP_063970.1 annexin A2

See identical proteins and their annotated locations for NP_063970.1

Status: PROVISIONAL

Source sequence(s)

X66871

UniProtKB/Swiss-Prot

Q07936

UniProtKB/TrEMBL

A0A8I6A0U3, A6KEW0

Related

ENSRNOP00000038428.6, ENSRNOT00000038677.6

Conserved Domains (1) summary

pfam00191
Location:109 → 174

Annexin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

78986252..79022638

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082021.2 → XP_038937949.1 annexin A2 isoform X1

UniProtKB/Swiss-Prot

Q07936

UniProtKB/TrEMBL

A0A8I6A0U3, A6KEW0

Related

ENSRNOP00000084769.1

Conserved Domains (1) summary

pfam00191
Location:109 → 174

Annexin