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ppp2r3b protein phosphatase 2, regulatory subunit B'', beta [ Danio rerio (zebrafish) ]

Gene ID: 566032, updated on 27-Mar-2024

Summary

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Official Symbol
ppp2r3bprovided by ZNC
Official Full Name
protein phosphatase 2, regulatory subunit B'', betaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070912-268
See related
Ensembl:ENSDARG00000076004 AllianceGenome:ZFIN:ZDB-GENE-070912-268
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:6895423; si:ch211-269e2.2
Summary
Predicted to enable protein phosphatase regulator activity. Predicted to be involved in protein dephosphorylation. Predicted to be part of protein phosphatase type 2A complex. Orthologous to human PPP2R3B (protein phosphatase 2 regulatory subunit B''beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 9
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (34484453..34509946, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (34675268..34698516, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene si:ch211-218d20.15 Neighboring gene si:ch211-269e2.1 Neighboring gene shox homeobox Neighboring gene cytokine receptor like factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A CRISPR/Cas9-generated mutation in the zebrafish orthologue of PPP2R3B causes idiopathic scoliosis. Seda M, et al. Sci Rep, 2023 Apr 26. PMID 37100808, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bone mineralization IMP
Inferred from Mutant Phenotype
more info
  
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    34484453..34509946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167860.3 → XP_005167917.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2

    UniProtKB/TrEMBL
    A0A8M2BFY8
    Conserved Domains (1) summary
    pfam13499
    Location:329 → 427
    EF-hand_7; EF-hand domain pair

  2. XM_689298.8 → XP_694390.3  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1

    UniProtKB/TrEMBL
    A0A8N7TFB5, B0S5T6
    Related
    ENSDARP00000104429.3, ENSDART00000113656.5
    Conserved Domains (1) summary
    pfam13499
    Location:330 → 428
    EF-hand_7; EF-hand domain pair

  3. XM_021478995.1 → XP_021334670.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X5

    UniProtKB/TrEMBL
    A0A8M9QKA7
    Conserved Domains (1) summary
    pfam13499
    Location:252 → 354
    EF-hand_7; EF-hand domain pair

  4. XM_021478994.1 → XP_021334669.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X4

    UniProtKB/TrEMBL
    A0A8M9QBH6
    Related
    ENSDARP00000101930.3, ENSDART00000114043.4
    Conserved Domains (1) summary
    pfam13499
    Location:253 → 355
    EF-hand_7; EF-hand domain pair

  5. XM_021478993.1 → XP_021334668.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

    UniProtKB/TrEMBL
    A0A8M9Q569
    Conserved Domains (1) summary
    pfam13499
    Location:257 → 359
    EF-hand_7; EF-hand domain pair
Nucleotide Protein Strain
Heading Accession and Version

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