cdc14ab cell division cycle 14Ab [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cdc14abprovided by ZNC
Official Full Name: cell division cycle 14Abprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070705-309
See related: Ensembl:ENSDARG00000057016 AllianceGenome:ZFIN:ZDB-GENE-070705-309
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-168j9.1
Summary: Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Predicted to be involved in cilium assembly; microtubule cytoskeleton organization; and regulation of cell cycle process. Predicted to act upstream of or within cell division and protein dephosphorylation. Predicted to be located in cell projection; cytoskeleton; and nucleus. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleolus. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 32. Orthologous to human CDC14A (cell division cycle 14A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 22

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (16191271..16270664, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (16165317..16244383, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of exit from mitosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in kinocilium	IEA Inferred from Electronic Annotation more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dual specificity protein phosphatase CDC14AB

Names: CDC14 cell division cycle 14 homolog A, b; CDC14 cell division cycle 14 homolog AB; cdc14a2; dual specificity protein phosphatase CDC14A

NP_001122010.1

EC 3.1.3.16

EC 3.1.3.48

XP_005161772.1

EC 3.1.3.16

EC 3.1.3.48

XP_005161774.1

EC 3.1.3.16

EC 3.1.3.48

XP_021325023.1

EC 3.1.3.16

EC 3.1.3.48

XP_021325024.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128538.1 → NP_001122010.1 dual specificity protein phosphatase CDC14AB

Status: PROVISIONAL

Source sequence(s)

BX908733, CR751228

UniProtKB/TrEMBL

A0A8M1NK61, A5PMX2

Related

ENSDARP00000096458.3, ENSDART00000105681.5

Conserved Domains (3) summary

COG2453
Location:191 → 367

CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]

pfam14671
Location:33 → 168

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:226 → 342

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007133.7 Reference GRCz11 Primary Assembly

Range

16191271..16270664 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021469348.1 → XP_021325023.1 dual specificity protein phosphatase CDC14AB isoform X2

UniProtKB/TrEMBL

A0A8M9PDX1

Related

ENSDARP00000139460.2, ENSDART00000171823.2

Conserved Domains (2) summary

COG2453
Location:191 → 367

CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]

pfam14671
Location:31 → 169

DSPn; Dual specificity protein phosphatase, N-terminal half
XM_005161715.4 → XP_005161772.1 dual specificity protein phosphatase CDC14AB isoform X1

UniProtKB/Swiss-Prot

A0A0R4IVA4

Conserved Domains (2) summary

COG2453
Location:191 → 367

CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]

pfam14671
Location:31 → 169

DSPn; Dual specificity protein phosphatase, N-terminal half
XM_021469349.1 → XP_021325024.1 dual specificity protein phosphatase CDC14AB isoform X3

UniProtKB/TrEMBL

A0A8M9PJL3

Conserved Domains (2) summary

COG2453
Location:117 → 293

CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]

pfam14671
Location:1 → 95

DSPn; Dual specificity protein phosphatase, N-terminal half
XM_005161717.4 → XP_005161774.1 dual specificity protein phosphatase CDC14AB isoform X4

UniProtKB/TrEMBL

A0A8M2B8K4

Conserved Domains (3) summary

COG2453
Location:191 → 367

CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]

pfam14671
Location:33 → 168

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:226 → 342

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...