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ppp2r3a protein phosphatase 2, regulatory subunit B'', alpha [ Danio rerio (zebrafish) ]

Gene ID: 565849, updated on 27-Mar-2024

Summary

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Official Symbol
ppp2r3aprovided by ZNC
Official Full Name
protein phosphatase 2, regulatory subunit B'', alphaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070912-646
See related
Ensembl:ENSDARG00000077722 AllianceGenome:ZFIN:ZDB-GENE-070912-646
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pr72; si:dkeyp-38b6.1
Summary
Predicted to enable protein phosphatase regulator activity. Acts upstream of or within heart looping and sarcomere organization. Predicted to be part of protein phosphatase type 2A complex. Is expressed in brain; liver; muscle; pericardial region; and pleuroperitoneal region. Orthologous to human PPP2R3A (protein phosphatase 2 regulatory subunit B''alpha). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (25173549..25293037)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (25517907..25636958)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene MSL complex subunit 2a Neighboring gene neutral cholesterol ester hydrolase 1a Neighboring gene fibronectin type III domain containing 3Ba Neighboring gene growth hormone secretagogue receptor a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Deletion of Pr130 Interrupts Cardiac Development in Zebrafish. Yang J, et al. Int J Mol Sci, 2016 Nov 11. PMID 27845735, Free PMC Article
  2. Deletion of Pr72 causes cardiac developmental defects in Zebrafish. Song G, et al. PLoS One, 2018. PMID 30481179, Free PMC Article
  3. Risk assessment of cardiotoxicity to zebrafish (Danio rerio) by environmental exposure to triclosan and its derivatives. Wang D, et al. Environ Pollut, 2020 Oct. PMID 32554097
  4. Surprising conservation of schizophrenia risk genes in lower organisms reflects their essential function and the evolution of genetic liability. Kasap M, et al. Schizophr Res, 2018 Dec. PMID 30017463
  5. Sequential, Divergent, and Cooperative Requirements of Foxl2a and Foxl2b in Ovary Development and Maintenance of Zebrafish. Yang YJ, et al. Genetics, 2017 Apr. PMID 28193729, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sarcomere organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
XP_005163463.1
XP_009296831.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    25173549..25293037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009298556.3 → XP_009296831.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_009296831.1

    UniProtKB/TrEMBL
    A0A8M3B7R1, E9QG28
    Related
    ENSDARP00000103598.3, ENSDART00000110922.4
    Conserved Domains (1) summary
    pfam13499
    Location:954 → 1052
    EF-hand_7; EF-hand domain pair

  2. XM_005163406.4 → XP_005163463.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8M2BAN2, B0S5Q0
    Related
    ENSDARP00000113838.1, ENSDART00000131977.3
    Conserved Domains (1) summary
    pfam13499
    Location:282 → 380
    EF-hand_7; EF-hand domain pair
Nucleotide Protein
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