ube2s ubiquitin-conjugating enzyme E2S [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ube2sprovided by ZNC
Official Full Name: ubiquitin-conjugating enzyme E2Sprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050913-92
See related: Ensembl:ENSDARG00000031775 AllianceGenome:ZFIN:ZDB-GENE-050913-92
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:114060
Summary: Predicted to enable ubiquitin conjugating enzyme activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including cellular protein metabolic process; free ubiquitin chain polymerization; and positive regulation of ubiquitin protein ligase activity. Predicted to act upstream of or within cell division. Predicted to be part of anaphase-promoting complex. Predicted to be active in nucleus. Orthologous to human UBE2S (ubiquitin conjugating enzyme E2 S). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (13672871..13680645, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (13782751..13790525, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	IEA Inferred from Electronic Annotation more info
contributes_to ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in anaphase-promoting complex-dependent catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in exit from mitosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in free ubiquitin chain polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K11-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ubiquitin-conjugating enzyme E2 S

Names: E2 ubiquitin-conjugating enzyme S; ubiquitin carrier protein S; ubiquitin-protein ligase S

NP_001020707.1

EC 2.3.2.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025536.1 → NP_001020707.1 ubiquitin-conjugating enzyme E2 S

See identical proteins and their annotated locations for NP_001020707.1

Status: PROVISIONAL

Source sequence(s)

BC097122

UniProtKB/Swiss-Prot

Q4V908

Related

ENSDARP00000047451.6, ENSDART00000047452.7

Conserved Domains (2) summary

COG5078
Location:10 → 157

COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

cd00195
Location:14 → 152

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...