U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

stat2 signal transducer and activator of transcription 2 [ Danio rerio (zebrafish) ]

Gene ID: 565200, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
stat2provided by ZNC
Official Full Name
signal transducer and activator of transcription 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-080321-1
See related
Ensembl:ENSDARG00000031647 AllianceGenome:ZFIN:ZDB-GENE-080321-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj84d07; wu:fj84d07
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; regulation of transcription by RNA polymerase II; and response to peptide hormone. Predicted to act upstream of or within regulation of transcription, DNA-templated and signal transduction. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Zika fever; immunodeficiency 44; and neutropenia. Orthologous to human STAT2 (signal transducer and activator of transcription 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See stat2 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
25
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (39123637..39178355, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (39126108..39180820, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene serine protease 60.3 Neighboring gene G protein-coupled receptor 84 Neighboring gene apolipoprotein F Neighboring gene tachykinin precursor 3b Neighboring gene core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1, like b

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. IRF9-Stat2 Fusion Protein as an Innate Immune Inducer to Activate Mx and Interferon-Stimulated Gene Expression in Zebrafish Larvae. Huang CJ, et al. Mar Biotechnol (NY), 2017 Jun. PMID 28500614
  2. Hypoxia induces myocardial regeneration in zebrafish. Jopling C, et al. Circulation, 2012 Dec 18. PMID 23151342
  3. Effects of starch-coating of magnetite nanoparticles on cellular uptake, toxicity and gene expression profiles in adult zebrafish. Zheng M, et al. Sci Total Environ, 2018 May 1. PMID 29227944
  4. Toxicity and Transcriptome Sequencing (RNA-seq) Analyses of Adult Zebrafish in Response to Exposure Carboxymethyl Cellulose Stabilized Iron Sulfide Nanoparticles. Zheng M, et al. Sci Rep, 2018 May 24. PMID 29795396, Free PMC Article
  5. Mutation of IFNLR1, an interferon lambda receptor 1, is associated with autosomal-dominant non-syndromic hearing loss. Gao X, et al. J Med Genet, 2018 May. PMID 29453195, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epithelium development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in type I interferon-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ISGF3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
signal transducer and activator of transcription 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271801.1 → NP_001258730.1  signal transducer and activator of transcription 2

    See identical proteins and their annotated locations for NP_001258730.1

    Status: VALIDATED

    Source sequence(s)
    CR847871, CR936541
    UniProtKB/TrEMBL
    A0A8M1NZ93, F8W3X1
    Conserved Domains (4) summary
    smart00964
    Location:2 → 121
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:141 → 312
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:314 → 559
    STAT_bind; STAT protein, DNA binding domain
    cl15255
    Location:550 → 692
    SH2; Src homology 2 (SH2) domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    39123637..39178355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017356505.2 → XP_017211994.1  signal transducer and activator of transcription 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M1NZ93, F8W3X1
    Conserved Domains (4) summary
    smart00964
    Location:2 → 121
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:141 → 312
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:314 → 559
    STAT_bind; STAT protein, DNA binding domain
    cl15255
    Location:550 → 692
    SH2; Src homology 2 (SH2) domain

  2. XM_005166048.4 → XP_005166105.1  signal transducer and activator of transcription 2 isoform X1

    See identical proteins and their annotated locations for XP_005166105.1

    UniProtKB/TrEMBL
    A0A8M1NZ93, F8W3X1
    Related
    ENSDARP00000124003.1, ENSDART00000148661.3
    Conserved Domains (4) summary
    smart00964
    Location:2 → 121
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:141 → 312
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:314 → 559
    STAT_bind; STAT protein, DNA binding domain
    cl15255
    Location:550 → 692
    SH2; Src homology 2 (SH2) domain

  3. XM_009302551.3 → XP_009300826.1  signal transducer and activator of transcription 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M3ATI0
    Related
    ENSDARP00000050681.8, ENSDART00000050682.8
    Conserved Domains (4) summary
    smart00964
    Location:2 → 121
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:141 → 312
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:314 → 559
    STAT_bind; STAT protein, DNA binding domain
    cl15255
    Location:550 → 692
    SH2; Src homology 2 (SH2) domain

  4. XM_017356506.2 → XP_017211995.1  signal transducer and activator of transcription 2 isoform X3

    UniProtKB/TrEMBL
    A0A8M6Z7C2

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394660.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    227907..228805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394661.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    1..34411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Tools
Miscellaneous