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Rbms2 RNA binding motif, single stranded interacting protein 2 [ Mus musculus (house mouse) ]

Gene ID: 56516, updated on 14-Apr-2024

Summary

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Official Symbol
Rbms2provided by MGI
Official Full Name
RNA binding motif, single stranded interacting protein 2provided by MGI
Primary source
MGI:MGI:1861776
See related
Ensembl:ENSMUSG00000040043 AllianceGenome:MGI:1861776
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Scr3; 2610315E04Rik
Summary
Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol and nucleus. Is expressed in central nervous system; genitourinary system; and sensory organ. Orthologous to human RBMS2 (RNA binding motif single stranded interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 29.7), mammary gland adult (RPKM 26.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rbms2 in Genome Data Viewer
Location:
10 D3; 10 76.41 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127965339..128016166, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128129470..128180297, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8377 Neighboring gene ATP synthase F1 subunit beta Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127529132-127529333 Neighboring gene STARR-positive B cell enhancer ABC_E8993 Neighboring gene STARR-seq mESC enhancer starr_28259 Neighboring gene microRNA 677 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127534859-127535012 Neighboring gene STARR-seq mESC enhancer starr_28261 Neighboring gene bromodomain adjacent to zinc finger domain, 2A Neighboring gene predicted gene, 51821 Neighboring gene STARR-positive B cell enhancer ABC_E11466 Neighboring gene STARR-seq mESC enhancer starr_28269 Neighboring gene STARR-positive B cell enhancer ABC_E11760 Neighboring gene predicted gene 4556 Neighboring gene glutaminase 2 (liver, mitochondrial) Neighboring gene SPRY domain containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Effects of SCR-3 on the immunosuppression accompanied with the systemic inflammatory response syndrome. Li J, et al. Mol Cell Biochem, 2012 May. PMID 22198336
  2. Structures and comparison of genomic and complementary DNAs of mouse MSSP, a c-Myc binding protein. Fujimoto M, et al. Int J Oncol, 2000 Feb. PMID 10639566
  3. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article
  4. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
  5. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(U) RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding motif, single-stranded-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039080.2 → NP_001034169.1  RNA-binding motif, single-stranded-interacting protein 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' sequence, which results in a different 5' UTR and a downstream AUG start codon, compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2 and 5 both encode the same isoform (b).
    Source sequence(s)
    AC135859, AC166817
    Consensus CDS
    CCDS24262.1
    UniProtKB/TrEMBL
    E9Q7G6, Q3UGN4
    Related
    ENSMUSP00000096742.2, ENSMUST00000099139.9
    Conserved Domains (2) summary
    cd12471
    Location:25 → 108
    RRM1_MSSP2; RNA recognition motif 1 (RRM1) found in vertebrate single-stranded DNA-binding protein MSSP-2
    cd12474
    Location:109 → 194
    RRM2_MSSP2; RNA recognition motif 2 (RRM2) found in vertebrate single-stranded DNA-binding protein MSSP-2

  2. NM_001429220.1 → NP_001416149.1  RNA-binding motif, single-stranded-interacting protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC135859, AC166817

  3. NM_001429221.1 → NP_001416150.1  RNA-binding motif, single-stranded-interacting protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC135859, AC166817

  4. NM_001429222.1 → NP_001416151.1  RNA-binding motif, single-stranded-interacting protein 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC135859, AC166817

  5. NM_001429223.1 → NP_001416152.1  RNA-binding motif, single-stranded-interacting protein 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC135859, AC166817

  6. NM_019711.3 → NP_062685.2  RNA-binding motif, single-stranded-interacting protein 2 isoform a

    See identical proteins and their annotated locations for NP_062685.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC135859, AC166817
    Consensus CDS
    CCDS24261.1
    UniProtKB/Swiss-Prot
    Q8VC70
    UniProtKB/TrEMBL
    Q3UGN4
    Related
    ENSMUSP00000089664.3, ENSMUST00000092033.4
    Conserved Domains (2) summary
    cd12474
    Location:137 → 222
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
    cl17169
    Location:53 → 136
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127965339..128016166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513900.3 → XP_006513963.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8VC70
    UniProtKB/TrEMBL
    Q3UGN4
    Conserved Domains (2) summary
    cd12474
    Location:137 → 222
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
    cl17169
    Location:53 → 136
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_036155899.1 → XP_036011792.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X2

    UniProtKB/TrEMBL
    E9Q7G6, Q3UGN4
    Conserved Domains (2) summary
    cd12471
    Location:25 → 108
    RRM1_MSSP2; RNA recognition motif 1 (RRM1) found in vertebrate single-stranded DNA-binding protein MSSP-2
    cd12474
    Location:109 → 194
    RRM2_MSSP2; RNA recognition motif 2 (RRM2) found in vertebrate single-stranded DNA-binding protein MSSP-2

  3. XM_006513899.2 → XP_006513962.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8VC70
    UniProtKB/TrEMBL
    Q3UGN4
    Conserved Domains (2) summary
    cd12474
    Location:137 → 222
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
    cl17169
    Location:53 → 136
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VC70.1 GenPept UniProtKB/Swiss-Prot:Q8VC70

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