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Ikbke inhibitor of kappaB kinase epsilon [ Mus musculus (house mouse) ]

Gene ID: 56489, updated on 21-Apr-2024

Summary

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Official Symbol
Ikbkeprovided by MGI
Official Full Name
inhibitor of kappaB kinase epsilonprovided by MGI
Primary source
MGI:MGI:1929612
See related
Ensembl:ENSMUSG00000042349 AllianceGenome:MGI:1929612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ikki; IKK-E; IKK-i; IKKepsilon
Summary
Enables IkappaB kinase activity; K48-linked polyubiquitin modification-dependent protein binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including interleukin-17-mediated signaling pathway; mRNA stabilization; and positive regulation of type I interferon-mediated signaling pathway. Predicted to be located in PML body and mitochondrial membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including future brain; sensory organ; submandibular gland primordium; thymus primordium; and turbinate bone primordium. Orthologous to human IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 20.8), large intestine adult (RPKM 16.0) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 E4; 1 56.93 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131182337..131207339, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131254600..131279601, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2D Neighboring gene STARR-positive B cell enhancer ABC_E11692 Neighboring gene STARR-seq mESC enhancer starr_02214 Neighboring gene Ras association (RalGDS/AF-6) domain family member 5 Neighboring gene bystin-like pseudogene Neighboring gene predicted gene 28913 Neighboring gene STARR-positive B cell enhancer ABC_E10034 Neighboring gene predicted gene, 51644 Neighboring gene SLIT-ROBO Rho GTPase activating protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E5796 Neighboring gene STARR-positive B cell enhancer ABC_E5797 Neighboring gene predicted gene, 53252 Neighboring gene STARR-seq mESC enhancer starr_02218 Neighboring gene STARR-positive B cell enhancer ABC_E23 Neighboring gene STARR-positive B cell enhancer ABC_E8941 Neighboring gene family with sequence similarity 72, member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. I-κB Kinase-ε Deficiency Attenuates the Development of Angiotensin II-Induced Myocardial Hypertrophy in Mice. Cao Y, et al. Oxid Med Cell Longev, 2021. PMID 33628362, Free PMC Article
  2. IKKε deficiency inhibits acute lung injury following renal ischemia reperfusion injury. Meng C, et al. Mol Med Rep, 2020 Nov. PMID 33000218, Free PMC Article
  3. A Novel Molecular Mechanism of IKKε-Mediated Akt/mTOR Inhibition in the Cardiomyocyte Autophagy after Myocardial Infarction. He S, et al. Oxid Med Cell Longev, 2020. PMID 32724494, Free PMC Article
  4. Hepatic IKKε expression is dispensable for high-fat feeding-induced increases in liver lipid content and alterations in glucose tolerance. Collier JJ, et al. Am J Physiol Endocrinol Metab, 2020 Jan 1. PMID 31661298, Free PMC Article
  5. IKKε aggravates inflammatory response via activation of NF-κB in rheumatoid arthritis. Zhou LF, et al. Eur Rev Med Pharmacol Sci, 2018 Apr. PMID 29687872

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Atypical inflammatory kinase IKBKE phosphorylates and inactivates FoxA1 to promote liver tumorigenesis.
    Title: Atypical inflammatory kinase IKBKE phosphorylates and inactivates FoxA1 to promote liver tumorigenesis.
  2. IKKepsilon and TBK1 prevent RIPK1 dependent and independent inflammation.
    Title: IKKε and TBK1 prevent RIPK1 dependent and independent inflammation.
  3. Inhibitor of nuclear factor kappa B kinase subunit epsilon regulates murine acetaminophen toxicity via RIPK1/JNK.
    Title: Inhibitor of nuclear factor kappa B kinase subunit epsilon regulates murine acetaminophen toxicity via RIPK1/JNK.
  4. Promotion of Knee Cartilage Degradation by IkappaB Kinase epsilon in the Pathogenesis of Osteoarthritis in Human and Murine Models.
    Title: Promotion of Knee Cartilage Degradation by IκB Kinase ε in the Pathogenesis of Osteoarthritis in Human and Murine Models.
  5. FGF21 is required for the metabolic benefits of IKKepsilon/TBK1 inhibition.
    Title: FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition.
  6. I-kappaB Kinase-epsilon Deficiency Attenuates the Development of Angiotensin II-Induced Myocardial Hypertrophy in Mice.
    Title: I-κB Kinase-ε Deficiency Attenuates the Development of Angiotensin II-Induced Myocardial Hypertrophy in Mice.
  7. IKKepsilon deficiency inhibits acute lung injury following renal ischemia reperfusion injury.
    Title: IKKε deficiency inhibits acute lung injury following renal ischemia reperfusion injury.
  8. IKK Epsilon Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice by Inhibiting Inflammation, Oxidative Stress, and Apoptosis.
    Title: IKK Epsilon Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice by Inhibiting Inflammation, Oxidative Stress, and Apoptosis.
  9. high levels of IKKepsilon might induce intractable inflammation via CXCL10.
    Title: CXCL10 production induced by high levels of IKKε in nasal airway epithelial cells in the setting of chronic inflammation.
  10. Results using mice with liver knockout of Ikbke suggest that the primary action of this kinase to impact insulin sensitivity during weight gain lies predominantly within extrahepatic tissues.
    Title: Hepatic IKKε expression is dispensable for high-fat feeding-induced increases in liver lipid content and alterations in glucose tolerance.
Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables IkappaB kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables K48-linked polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables K48-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in interleukin-17-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to interferon-beta ISO
Inferred from Sequence Orthology
more info
  
involved_in response to type I interferon IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inhibitor of nuclear factor kappa-B kinase subunit epsilon
Names
I-kappa-B kinase epsilon
IKK-epsilon
inducible I kappa-B kinase
inducible IKappaB kinase
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
NP_062751.2
XP_006529826.1
XP_006529827.1
XP_011246354.1
XP_017177332.1
XP_036008385.1
XP_036008388.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019777.3 → NP_062751.2  inhibitor of nuclear factor kappa-B kinase subunit epsilon

    See identical proteins and their annotated locations for NP_062751.2

    Status: VALIDATED

    Source sequence(s)
    AK088580
    Consensus CDS
    CCDS15269.1
    UniProtKB/Swiss-Prot
    Q8C2I3, Q9R0T8
    UniProtKB/TrEMBL
    Q3U6P9
    Related
    ENSMUSP00000054126.4, ENSMUST00000062108.10
    Conserved Domains (3) summary
    cd17128
    Location:308 → 383
    Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)
    pfam18394
    Location:402 → 648
    TBK1_CCD1; TANK-binding kinase 1 coiled-coil domain 1
    cl21453
    Location:15 → 330
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    131182337..131207339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248052.4 → XP_011246354.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1

    See identical proteins and their annotated locations for XP_011246354.1

    UniProtKB/Swiss-Prot
    Q8C2I3, Q9R0T8
    UniProtKB/TrEMBL
    Q3U6P9
    Related
    ENSMUSP00000124190.2, ENSMUST00000161764.8
    Conserved Domains (3) summary
    cd17128
    Location:308 → 383
    Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)
    pfam18394
    Location:402 → 648
    TBK1_CCD1; TANK-binding kinase 1 coiled-coil domain 1
    cl21453
    Location:15 → 330
    PKc_like; Protein Kinases, catalytic domain

  2. XM_036152492.1 → XP_036008385.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2

    Conserved Domains (3) summary
    cd17128
    Location:308 → 383
    Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)
    pfam18394
    Location:402 → 568
    TBK1_CCD1; TANK-binding kinase 1 coiled-coil domain 1
    cl21453
    Location:15 → 330
    PKc_like; Protein Kinases, catalytic domain

  3. XM_006529764.4 → XP_006529827.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X5

    Conserved Domains (3) summary
    cd17128
    Location:308 → 383
    Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)
    pfam18394
    Location:402 → 479
    TBK1_CCD1; TANK-binding kinase 1 coiled-coil domain 1
    cl21453
    Location:15 → 330
    PKc_like; Protein Kinases, catalytic domain

  4. XM_006529763.4 → XP_006529826.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X4

    Conserved Domains (3) summary
    cd17128
    Location:308 → 383
    Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)
    pfam18394
    Location:402 → 479
    TBK1_CCD1; TANK-binding kinase 1 coiled-coil domain 1
    cl21453
    Location:15 → 330
    PKc_like; Protein Kinases, catalytic domain

  5. XM_017321843.2 → XP_017177332.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X3

    Conserved Domains (3) summary
    cd17128
    Location:308 → 383
    Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)
    pfam18394
    Location:402 → 479
    TBK1_CCD1; TANK-binding kinase 1 coiled-coil domain 1
    cl21453
    Location:15 → 330
    PKc_like; Protein Kinases, catalytic domain

  6. XM_036152495.1 → XP_036008388.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X6

    Conserved Domains (2) summary
    cd17128
    Location:308 → 383
    Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)
    cl21453
    Location:15 → 330
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_387186.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0T8.2 GenPept UniProtKB/Swiss-Prot:Q9R0T8

Gene LinkOut

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