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irf3 interferon regulatory factor 3 [ Danio rerio (zebrafish) ]

Gene ID: 564854, updated on 4-Jan-2025

Summary

Official Symbol
irf3provided by ZNC
Official Full Name
interferon regulatory factor 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-071120-7
See related
Ensembl:ENSDARG00000076251 AllianceGenome:ZFIN:ZDB-GENE-071120-7
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Enables transcription cis-regulatory region binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to act upstream of or within regulation of DNA-templated transcription. Is expressed in head kidney. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human IRF3 (interferon regulatory factor 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See irf3 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (4580243..4598237, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (4541598..4563408, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496766 Neighboring gene si:dkey-94f20.4 Neighboring gene proline rich 12a Neighboring gene BR serine/threonine kinase 1a

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by ZFIN

General protein information

Preferred Names
interferon regulatory factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143904.1NP_001137376.1  interferon regulatory factor 3

    See identical proteins and their annotated locations for NP_001137376.1

    Status: PROVISIONAL

    Source sequence(s)
    EU274623
    UniProtKB/TrEMBL
    A0A8M1NQX6, B7SEE0
    Related
    ENSDARP00000099633.1, ENSDART00000110104.2
    Conserved Domains (2) summary
    pfam00605
    Location:7107
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:203390
    IRF-3; Interferon-regulatory factor 3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    4580243..4598237 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017358468.3XP_017213957.1  interferon regulatory factor 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z9B8
    Conserved Domains (2) summary
    pfam00605
    Location:7107
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:246408
    IRF-3; Interferon-regulatory factor 3
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