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zyx zyxin [ Danio rerio (zebrafish) ]

Gene ID: 564246, updated on 27-Mar-2024

Summary

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Official Symbol
zyxprovided by ZNC
Official Full Name
zyxinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070928-18
See related
Ensembl:ENSDARG00000075733 AllianceGenome:ZFIN:ZDB-GENE-070928-18
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:171680
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in integrin-mediated signaling pathway and transforming growth factor beta receptor signaling pathway. Predicted to be active in cytoplasm; focal adhesion; and stress fiber. Orthologous to human ZYX (zyxin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 16
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (17300495..17347899, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (17393992..17439927, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene EMG1 N1-specific pseudouridine methyltransferase Neighboring gene Kell metallo-endopeptidase (Kell blood group) Neighboring gene family with sequence similarity 131 member Bb Neighboring gene chloride channel, voltage-sensitive 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cytoskeletal Protein Zyxin Inhibits the Activity of Genes Responsible for Embryonic Stem Cell Status. Parshina EA, et al. Cell Rep, 2020 Nov 17. PMID 33207197
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zyxin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109824.1 → NP_001103294.1  zyxin

    See identical proteins and their annotated locations for NP_001103294.1

    Status: PROVISIONAL

    Source sequence(s)
    BC151921
    UniProtKB/TrEMBL
    A7MBU7
    Conserved Domains (1) summary
    cl02475
    Location:360 → 426
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    17300495..17347899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021466716.1 → XP_021322391.1  zyxin isoform X1

    UniProtKB/TrEMBL
    A0A8M2B4S6, F1QC03
    Related
    ENSDARP00000118075.1, ENSDART00000144392.2
    Conserved Domains (2) summary
    cd09435
    Location:537 → 603
    LIM3_Zyxin; The third LIM domain of Zyxin
    cl02475
    Location:383 → 470
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. XM_005157926.4 → XP_005157983.1  zyxin isoform X1

    See identical proteins and their annotated locations for XP_005157983.1

    UniProtKB/TrEMBL
    A0A8M2B4S6, F1QC03
    Related
    ENSDARP00000113371.1, ENSDART00000143056.3
    Conserved Domains (2) summary
    cd09435
    Location:537 → 603
    LIM3_Zyxin; The third LIM domain of Zyxin
    cl02475
    Location:383 → 470
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. XM_021466717.1 → XP_021322392.1  zyxin isoform X2

    UniProtKB/TrEMBL
    A0A8M9NZB7
    Conserved Domains (2) summary
    cd09435
    Location:383 → 449
    LIM3_Zyxin; The third LIM domain of Zyxin
    cl02475
    Location:229 → 316
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
Nucleotide Protein
Heading Accession and Version

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