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Shoc2 Shoc2, leucine rich repeat scaffold protein [ Mus musculus (house mouse) ]

Gene ID: 56392, updated on 2-Apr-2024

Summary

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Official Symbol
Shoc2provided by MGI
Official Full Name
Shoc2, leucine rich repeat scaffold proteinprovided by MGI
Primary source
MGI:MGI:1927197
See related
Ensembl:ENSMUSG00000024976 AllianceGenome:MGI:1927197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sur8; mKIAA0862
Summary
Predicted to enable protein phosphatase 1 binding activity. Predicted to be involved in positive regulation of Ras protein signal transduction and signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein phosphatase type 1 complex. Is expressed in dorsal root ganglion; facial ganglion; glossopharyngeal ganglion; and trigeminal ganglion. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 1. Orthologous to human SHOC2 (SHOC2 leucine rich repeat scaffold protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 12.8), placenta adult (RPKM 12.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 D2; 19 48.83 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (53932018..54021711)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (53944232..54033280)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 20 Neighboring gene STARR-seq mESC enhancer starr_46468 Neighboring gene STARR-seq mESC enhancer starr_46470 Neighboring gene predicted gene 16299 Neighboring gene STARR-positive B cell enhancer ABC_E8757 Neighboring gene STARR-positive B cell enhancer ABC_E11040 Neighboring gene predicted gene, 30990 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:53965483-53965684 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:53968181-53968334 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:53968382-53968491 Neighboring gene STARR-positive B cell enhancer ABC_E622 Neighboring gene STARR-seq mESC enhancer starr_46471 Neighboring gene STARR-seq mESC enhancer starr_46472 Neighboring gene programmed cell death 4 Neighboring gene STARR-seq mESC enhancer starr_46473 Neighboring gene BBSome interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_46474 Neighboring gene STARR-seq mESC enhancer starr_46476 Neighboring gene adrenergic receptor, alpha 2a Neighboring gene STARR-seq mESC enhancer starr_46477 Neighboring gene predicted gene, 41865

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SHOC2 subcellular shuttling requires the KEKE motif-rich region and N-terminal leucine-rich repeat domain and impacts on ERK signalling. Motta M, et al. Hum Mol Genet, 2016 Sep 1. PMID 27466182
  2. SHOC2 mediates the drug-resistance of triple-negative breast cancer cells to everolimus. Geng W, et al. Cancer Biol Ther, 2023 Dec 31. PMID 37170083, Free PMC Article
  3. The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model. Tan M, et al. Cell Rep, 2022 Dec 20. PMID 36543126
  4. Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development. Yi J, et al. Dev Dyn, 2010 Jul. PMID 20549726, Free PMC Article
  5. Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex. Dai P, et al. J Biol Chem, 2006 Jan 13. PMID 16301319

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SHOC2 mediates the drug-resistance of triple-negative breast cancer cells to everolimus.
    Title: SHOC2 mediates the drug-resistance of triple-negative breast cancer cells to everolimus.
  2. The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model.
    Title: The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model.
  3. Results provide evidence that SHOC2 trapping at different subcellular sites has a diverse impact on ERK signaling strength and dynamics, suggesting a dual counteracting modulatory role of SHOC2 in the control of ERK signaling exerted at different intracellular compartments.
    Title: SHOC2 subcellular shuttling requires the KEKE motif-rich region and N-terminal leucine-rich repeat domain and impacts on ERK signalling.
  4. Data suggest that SUR-8 may act in an ERK-independent pathway to regulate AVC development.
    Title: Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development.
  5. Erbin has a regulatory role in the Ras-Raf-MEK pathway and may inhibit ERK activation by disrupting the Sur-8-Ras/Raf interaction
    Title: Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102442

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein phosphatase 1 binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cyclic-GMP-AMP transmembrane import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in nerve growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein phosphatase type 1 complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
leucine-rich repeat protein SHOC-2
Names
Ras-binding protein SUR-8
protein soc-2 homolog
protein sur-8 homolog
soc-2 (suppressor of clear) homolog
soc-2-like protein
suppressor of clear, C. elegans, homolog of

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168505.1 → NP_001161977.1  leucine-rich repeat protein SHOC-2

    See identical proteins and their annotated locations for NP_001161977.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC117612
    Consensus CDS
    CCDS29904.1
    UniProtKB/Swiss-Prot
    O88520, Q3UJH6, Q8BVL0, Q91VH8
    Related
    ENSMUSP00000127932.2, ENSMUST00000169861.9
    Conserved Domains (3) summary
    PLN03150
    Location:453 → 527
    PLN03150; hypothetical protein; Provisional
    PLN00113
    Location:115 → 483
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:240 → 262
    LRR_RI; leucine-rich repeat [structural motif]

  2. NM_001355242.2 → NP_001342171.1  leucine-rich repeat protein SHOC-2

    Status: VALIDATED

    Source sequence(s)
    AC117612
    Consensus CDS
    CCDS29904.1
    UniProtKB/Swiss-Prot
    O88520, Q3UJH6, Q8BVL0, Q91VH8
    Conserved Domains (3) summary
    PLN03150
    Location:453 → 527
    PLN03150; hypothetical protein; Provisional
    PLN00113
    Location:115 → 483
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:240 → 262
    LRR_RI; leucine-rich repeat [structural motif]

  3. NM_001414663.1 → NP_001401592.1  leucine-rich repeat protein SHOC-2

    Status: VALIDATED

    Source sequence(s)
    AC117612
    UniProtKB/Swiss-Prot
    O88520, Q3UJH6, Q8BVL0, Q91VH8

  4. NM_001414664.1 → NP_001401593.1  leucine-rich repeat protein SHOC-2

    Status: VALIDATED

    Source sequence(s)
    AC117612
    UniProtKB/Swiss-Prot
    O88520, Q3UJH6, Q8BVL0, Q91VH8

  5. NM_019658.7 → NP_062632.2  leucine-rich repeat protein SHOC-2

    See identical proteins and their annotated locations for NP_062632.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC117612
    Consensus CDS
    CCDS29904.1
    UniProtKB/Swiss-Prot
    O88520, Q3UJH6, Q8BVL0, Q91VH8
    Related
    ENSMUSP00000025932.8, ENSMUST00000025932.9
    Conserved Domains (3) summary
    PLN03150
    Location:453 → 527
    PLN03150; hypothetical protein; Provisional
    PLN00113
    Location:115 → 483
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:240 → 262
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    53932018..54021711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527228.5 → XP_006527291.1  leucine-rich repeat protein SHOC-2 isoform X1

    See identical proteins and their annotated locations for XP_006527291.1

    UniProtKB/Swiss-Prot
    O88520, Q3UJH6, Q8BVL0, Q91VH8
    Conserved Domains (3) summary
    PLN03150
    Location:453 → 527
    PLN03150; hypothetical protein; Provisional
    PLN00113
    Location:115 → 483
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:240 → 262
    LRR_RI; leucine-rich repeat [structural motif]

  2. XM_036161642.1 → XP_036017535.1  leucine-rich repeat protein SHOC-2 isoform X1

    UniProtKB/Swiss-Prot
    O88520, Q3UJH6, Q8BVL0, Q91VH8
    Conserved Domains (3) summary
    PLN03150
    Location:453 → 527
    PLN03150; hypothetical protein; Provisional
    PLN00113
    Location:115 → 483
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:240 → 262
    LRR_RI; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88520.2 GenPept UniProtKB/Swiss-Prot:O88520

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