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ncoa1 nuclear receptor coactivator 1 [ Danio rerio (zebrafish) ]

Gene ID: 563288, updated on 27-Mar-2024

Summary

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Official Symbol
ncoa1provided by ZNC
Official Full Name
nuclear receptor coactivator 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-041001-175
See related
Ensembl:ENSDARG00000018257 AllianceGenome:ZFIN:ZDB-GENE-041001-175
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-5g7.1; si:dkey-5g7.6; si:dkey-34f16.6
Summary
Predicted to enable nuclear receptor binding activity and nuclear receptor coactivator activity. Predicted to be involved in cellular response to hormone stimulus and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be active in nucleus. Is expressed in axis; central nervous system; intestinal bulb; liver; and presumptive diencephalon. Orthologous to human NCOA1 (nuclear receptor coactivator 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 20
Exon count:
23
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (36682063..36792704)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (36779197..36889280)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 member 6a Neighboring gene ribosomal protein L7-like 1 Neighboring gene solute carrier family 25 member 27 Neighboring gene peptidyl-tRNA hydrolase domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. An F-domain introduced by alternative splicing regulates activity of the zebrafish thyroid hormone receptor alpha. Takayama S, et al. Gen Comp Endocrinol, 2008 Jan 1. PMID 17583703, Free PMC Article
  2. Distinct Molecular Signature of Murine Fetal Liver and Adult Hematopoietic Stem Cells Identify Novel Regulators of Hematopoietic Stem Cell Function. Manesia JK, et al. Stem Cells Dev, 2017 Apr 15. PMID 27958775, Free PMC Article
  3. Effects of thyroid hormone disruption on the ontogenetic expression of thyroid hormone signaling genes in developing zebrafish (Danio rerio). Walter KM, et al. Gen Comp Endocrinol, 2019 Feb 1. PMID 30448381, Free PMC Article
  4. Behavioral and physiological effects of acute and chronic kava exposure in adult zebrafish. Wang D, et al. Neurotoxicol Teratol, 2020 May-Jun. PMID 32240749
  5. Pharmacokinetics and effects of tetrabromobisphenol a (TBBPA) to early life stages of zebrafish (Danio rerio). Liu H, et al. Chemosphere, 2018 Jan. PMID 28992476

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables nuclear receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor coactivator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear receptor coactivator 1
Names
DKEY-34F16.7
SRC1
XP_009293149.1
XP_021324335.1
XP_691744.5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    36682063..36792704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_686652.8 → XP_691744.5  nuclear receptor coactivator 1 isoform X1

    See identical proteins and their annotated locations for XP_691744.5

    UniProtKB/TrEMBL
    A0A8M9PTD7, F1Q717, Q5RIG3
    Related
    ENSDARP00000111627.3, ENSDART00000130513.5
    Conserved Domains (6) summary
    smart00353
    Location:35 → 89
    HLH; helix loop helix domain
    smart00091
    Location:121 → 178
    PAS; PAS domain
    pfam07469
    Location:1150 → 1206
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:869 → 913
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam14598
    Location:267 → 376
    PAS_11; PAS domain
    cl26464
    Location:384 → 670
    Atrophin-1; Atrophin-1 family

  2. XM_009294874.3 → XP_009293149.1  nuclear receptor coactivator 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AWF7
    Conserved Domains (7) summary
    smart00353
    Location:35 → 89
    HLH; helix loop helix domain
    smart00091
    Location:121 → 178
    PAS; PAS domain
    pfam07469
    Location:1113 → 1169
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:832 → 876
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:572 → 605
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:267 → 376
    PAS_11; PAS domain
    pfam16665
    Location:445 → 535
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  3. XM_021468660.1 → XP_021324335.1  nuclear receptor coactivator 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PTD7, F1Q717, Q5RIG3
    Related
    ENSDARP00000045947.7, ENSDART00000045948.7
    Conserved Domains (6) summary
    smart00353
    Location:35 → 89
    HLH; helix loop helix domain
    smart00091
    Location:121 → 178
    PAS; PAS domain
    pfam07469
    Location:1150 → 1206
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:869 → 913
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam14598
    Location:267 → 376
    PAS_11; PAS domain
    cl26464
    Location:384 → 670
    Atrophin-1; Atrophin-1 family
Nucleotide Protein Strain
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