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gdf10a growth differentiation factor 10a [ Danio rerio (zebrafish) ]

Gene ID: 563003, updated on 27-Mar-2024

Summary

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Official Symbol
gdf10aprovided by ZNC
Official Full Name
growth differentiation factor 10aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-090312-17
See related
Ensembl:ENSDARG00000095378 AllianceGenome:ZFIN:ZDB-GENE-090312-17
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7147834; si:ch211-134j6.3; si:ch211-134j6.6
Summary
Predicted to enable cytokine activity. Predicted to be involved in SMAD protein signal transduction and positive regulation of pathway-restricted SMAD protein phosphorylation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including Bergmann glial cell; hypophysis; musculature system; otic vesicle; and sensory system. Orthologous to human GDF10 (growth differentiation factor 10). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 13
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (31285617..31290845)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (31155166..31160395)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 22 Neighboring gene mitogen-activated protein kinase 8a Neighboring gene protein tyrosine phosphatase non-receptor type 20 Neighboring gene zinc finger protein 488 Neighboring gene ANTXR cell adhesion molecule 1d

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma. Venkatesan AM, et al. J Clin Invest, 2018 Jan 2. PMID 29202482, Free PMC Article
  2. Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. Takeuchi M, et al. J Comp Neurol, 2017 May 1. PMID 27615194
  3. A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Xue Y, et al. Cell Rep, 2019 Apr 30. PMID 31042481
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of osteoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
bone morphogenetic protein 3B; growth/differentiation factor 10

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    31285617..31290845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_686367.7 → XP_691459.3  growth/differentiation factor 10

    UniProtKB/TrEMBL
    A0A8N7T7I5, B8A5X9
    Related
    ENSDARP00000117036.1, ENSDART00000148352.2
    Conserved Domains (1) summary
    pfam00019
    Location:337 → 440
    TGF_beta; Transforming growth factor beta like domain
Nucleotide Protein Strain
Heading Accession and Version

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