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pmelb premelanosome protein b [ Danio rerio (zebrafish) ]

Gene ID: 562810, updated on 11-Apr-2024

Summary

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Official Symbol
pmelbprovided by ZNC
Official Full Name
premelanosome protein bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050912-2
See related
Ensembl:ENSDARG00000033760 AllianceGenome:ZFIN:ZDB-GENE-050912-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
silvb; silverb
Summary
Acts upstream of or within melanosome organization. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in melanosome. Predicted to be integral component of plasma membrane. Is expressed in optic vesicle; presumptive retinal pigmented epithelium; retina; and retinal pigmented epithelium. Orthologous to human PMEL (premelanosome protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 23
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (35672504..35690339)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (35573728..35591533)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 18 Neighboring gene cyclin T1 Neighboring gene uncharacterized LOC110438325 Neighboring gene tubulin, alpha 1c Neighboring gene tubulin, alpha 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A mutation in the silver gene leads to defects in melanosome biogenesis and alterations in the visual system in the zebrafish mutant fading vision. Schonthaler HB, et al. Dev Biol, 2005 Aug 15. PMID 16024012
  2. Non-Synonymous variants in premelanosome protein (PMEL) cause ocular pigment dispersion and pigmentary glaucoma. Lahola-Chomiak AA, et al. Hum Mol Genet, 2019 Apr 15. PMID 30561643, Free PMC Article
  3. Regulation of melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL. Burgoyne T, et al. J Cell Sci, 2015 Apr 1. PMID 25690007, Free PMC Article
  4. Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-propyl-2-thiouracil in zebrafish embryos. Liu C, et al. Aquat Toxicol, 2012 Aug 15. PMID 22542736
  5. Otx but not Mitf transcription factors are required for zebrafish retinal pigment epithelium development. Lane BM, et al. PLoS One, 2012. PMID 23139843, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in melanosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within melanosome organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in melanosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
melanocyte protein Pmel 17; premelanosome protein b
Names
melanosome matrix protein
silver homolog b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033918.2 → NP_001029090.2  premelanosome protein b precursor

    See identical proteins and their annotated locations for NP_001029090.2

    Status: PROVISIONAL

    Source sequence(s)
    BC116462
    UniProtKB/TrEMBL
    Q1JQ71
    Related
    ENSDARP00000046267.5, ENSDART00000046268.7
    Conserved Domains (1) summary
    pfam00801
    Location:221 → 285
    PKD; PKD domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    35672504..35690339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162378.4 → XP_005162435.1  melanocyte protein Pmel 17 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B993
    Conserved Domains (1) summary
    pfam00801
    Location:221 → 285
    PKD; PKD domain
Nucleotide Protein
Heading Accession and Version

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