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zbtb33 zinc finger and BTB domain containing 33 [ Danio rerio (zebrafish) ]

Gene ID: 562507, updated on 27-Mar-2024

Summary

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Official Symbol
zbtb33provided by ZNC
Official Full Name
zinc finger and BTB domain containing 33provided by ZNC
Primary source
ZFIN:ZDB-GENE-070412-3
See related
Ensembl:ENSDARG00000071467 AllianceGenome:ZFIN:ZDB-GENE-070412-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7147506; wu:fd36e09
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleoplasm. Orthologous to human ZBTB33 (zinc finger and BTB domain containing 33). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 14
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (33427803..33435854)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (33087497..33095542)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A1 Neighboring gene NFKB activating protein Neighboring gene transmembrane protein 255A Neighboring gene ATPase Na+/K+ transporting subunit beta 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Kzp regulates the transcription of gata2 and pu.1 during primitive hematopoiesis in zebrafish embryos. Liu F, et al. J Genet Genomics, 2012 Sep 20. PMID 23021546
  2. Chaperone-Mediated Autophagy in the Light of Evolution: Insight from Fish. Lescat L, et al. Mol Biol Evol, 2020 Oct 1. PMID 32437540
  3. Comparative phosphoproteomics of zebrafish Fyn/Yes morpholino knockdown embryos. Lemeer S, et al. Mol Cell Proteomics, 2008 Nov. PMID 18550893
  4. A subtracted cDNA library from the zebrafish (Danio rerio) embryonic inner ear. Coimbra RS, et al. Genome Res, 2002 Jun. PMID 12045154, Free PMC Article
  5. Apela Regulates Fluid Homeostasis by Binding to the APJ Receptor to Activate Gi Signaling. Deng C, et al. J Biol Chem, 2015 Jul 24. PMID 25995451, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our results indicate that Kzp is a critical transcriptional factor for the expression of gata2 and pu.1 to modulate primitive hematopoiesis.
    Title: Kzp regulates the transcription of gata2 and pu.1 during primitive hematopoiesis in zebrafish embryos.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcriptional regulator Kaiso

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100008.1 → NP_001093478.1  transcriptional regulator Kaiso

    See identical proteins and their annotated locations for NP_001093478.1

    Status: PROVISIONAL

    Source sequence(s)
    BC142938
    UniProtKB/TrEMBL
    A5PLK1
    Related
    ENSDARP00000096464.4, ENSDART00000105687.6
    Conserved Domains (4) summary
    smart00225
    Location:33 → 116
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:432 → 452
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:23 → 116
    BTB; BTB/POZ domain
    pfam13465
    Location:444 → 468
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    33427803..33435854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005173251.4 → XP_005173308.1  transcriptional regulator Kaiso isoform X1

    See identical proteins and their annotated locations for XP_005173308.1

    UniProtKB/TrEMBL
    A0A8M2BKK2, A8DU70
    Conserved Domains (4) summary
    smart00225
    Location:33 → 116
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:432 → 452
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:23 → 116
    BTB; BTB/POZ domain
    pfam13465
    Location:444 → 468
    zf-H2C2_2; Zinc-finger double domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394917.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    391706..397246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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