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shc2 SHC (Src homology 2 domain containing) transforming protein 2 [ Danio rerio (zebrafish) ]

Gene ID: 562011, updated on 11-Apr-2024

Summary

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Official Symbol
shc2provided by ZNC
Official Full Name
SHC (Src homology 2 domain containing) transforming protein 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-050208-666
See related
Ensembl:ENSDARG00000062080 AllianceGenome:ZFIN:ZDB-GENE-050208-666
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:162768; si:dkey-94n12.3
Summary
Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within intracellular signal transduction. Predicted to be active in plasma membrane. Orthologous to human SHC2 (SHC adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 22
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (21317443..21352422)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (21292500..21327555)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene CIMAP1 family member D Neighboring gene CDC28 protein kinase regulatory subunit 2 Neighboring gene ankyrin repeat domain 24 Neighboring gene Src homology 2 domain containing transforming protein D, b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish. Yang BY, et al. Am J Physiol Endocrinol Metab, 2018 Jul 1. PMID 29351486
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC162768

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SHC-transforming protein 2
Names
src homology 2 domain containing transforming protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044973.1 → NP_001038438.1  SHC-transforming protein 2

    Status: PROVISIONAL

    Source sequence(s)
    BX470234
    UniProtKB/TrEMBL
    A0A8M1N9W8, Q1LX18
    Related
    ENSDARP00000114455.1, ENSDART00000132605.3
    Conserved Domains (2) summary
    cd09925
    Location:398 → 500
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:28 → 198
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    21317443..21352422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009296255.3 → XP_009294530.1  SHC-transforming protein 2 isoform X3

    See identical proteins and their annotated locations for XP_009294530.1

    UniProtKB/TrEMBL
    A0A8M3AUP6
    Conserved Domains (2) summary
    cd09925
    Location:389 → 491
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:28 → 198
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

  2. XM_005170462.4 → XP_005170519.2  SHC-transforming protein 2 isoform X3

    See identical proteins and their annotated locations for XP_005170519.2

    UniProtKB/TrEMBL
    A0A8M3AUP6
    Conserved Domains (2) summary
    cd09925
    Location:389 → 491
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:28 → 198
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

  3. XM_017353157.2 → XP_017208646.1  SHC-transforming protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M6YXA6

  4. XM_017353158.2 → XP_017208647.1  SHC-transforming protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z438

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395104.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    20955..54827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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