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wnt6b wingless-type MMTV integration site family, member 6b [ Danio rerio (zebrafish) ]

Gene ID: 561831, updated on 27-Mar-2024

Summary

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Official Symbol
wnt6bprovided by ZNC
Official Full Name
wingless-type MMTV integration site family, member 6bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070912-513
See related
Ensembl:ENSDARG00000073935 AllianceGenome:ZFIN:ZDB-GENE-070912-513
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-31m21.2
Summary
Predicted to enable cytokine activity and frizzled binding activity. Predicted to be involved in canonical Wnt signaling pathway; cell fate commitment; and neuron differentiation. Predicted to act upstream of or within Wnt signaling pathway. Predicted to be located in extracellular region and membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Is expressed in eye. Orthologous to human WNT6 (Wnt family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (11282224..11341351)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (11311060..11370613)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene acid-sensing (proton-gated) ion channel family member 4a Neighboring gene chondroitin polymerizing factor a Neighboring gene wingless-type MMTV integration site family, member 10a Neighboring gene cyclin dependent kinase 5, regulatory subunit 2b (p39)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Transcriptomic Responses of Bisphenol S Predict Involvement of Immune Function in the Cardiotoxicity of Early Life-Stage Zebrafish (Danio rerio). Qiu W, et al. Environ Sci Technol, 2020 Mar 3. PMID 31888327
  2. PITX2 deficiency and associated human disease: insights from the zebrafish model. Hendee KE, et al. Hum Mol Genet, 2018 May 15. PMID 29506241, Free PMC Article
  3. Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration. Peng X, et al. J Mol Cell Biol, 2021 Apr 10. PMID 33582796, Free PMC Article
  4. CFTR regulates embryonic T lymphopoiesis via Wnt signaling in zebrafish. Lin Z, et al. Immunol Lett, 2021 Jun. PMID 33951474
  5. Ascl1a/Dkk/beta-catenin signaling pathway is necessary and glycogen synthase kinase-3beta inhibition is sufficient for zebrafish retina regeneration. Ramachandran R, et al. Proc Natl Acad Sci U S A, 2011 Sep 20. PMID 21911394, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein Wnt-6
Names
wingless-type MMTV integration site family, member 6
wnt6

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    11282224..11341351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003199189.5 → XP_003199237.2  protein Wnt-6

    UniProtKB/TrEMBL
    A0A8M1RNK5, F1R205
    Related
    ENSDARP00000104431.2, ENSDART00000110691.4
    Conserved Domains (1) summary
    pfam00110
    Location:47 → 354
    wnt; wnt family
Nucleotide Protein
Heading Accession and Version

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