U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [ Danio rerio (zebrafish) ]

Gene ID: 561737, updated on 25-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
pik3caprovided by ZNC
Official Full Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alphaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-130409-1
See related
Ensembl:ENSDARG00000075456 AllianceGenome:ZFIN:ZDB-GENE-130409-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable phosphatidylinositol-3,4-bisphosphate 5-kinase activity and phosphatidylinositol-4,5-bisphosphate 3-kinase activity. Acts upstream of or within regulation of collateral sprouting in absence of injury. Is expressed in eye and male organism. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome 5; breast cancer (multiple); cutaneous Paget's disease; and gastrointestinal system cancer (multiple). Orthologous to human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 11
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (34484780..34522237, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (34222681..34260194, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103911849 Neighboring gene xyloside xylosyltransferase 1 Neighboring gene zinc finger, matrin-type 3 Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4a

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Deciphering combinations of PI3K/AKT/mTOR pathway drugs augmenting anti-angiogenic efficacy in vivo. Sasore T, et al. PLoS One, 2014. PMID 25144531, Free PMC Article
  2. A role for the polarity complex and PI3 kinase in branch formation within retinotectal arbors of zebrafish. Schmidt JT, et al. Dev Neurobiol, 2014 Jun. PMID 24218155
  3. Leucine mediates autophagosome-lysosome fusion and improves sperm motility by activating the PI3K/Akt pathway. Zhang J, et al. Oncotarget, 2017 Dec 19. PMID 29340093, Free PMC Article
  4. Anticonvulsant action of a selective phosphatidylinositol-3-kinase inhibitor LY294002 in pentylenetetrazole-mediated convulsions in zebrafish. Mazumder AG, et al. Epilepsy Res, 2019 Nov. PMID 31563029
  5. Target identification, screening and in vivo evaluation of pyrrolone-fused benzosuberene compounds against human epilepsy using Zebrafish model of pentylenetetrazol-induced seizures. Tanwar G, et al. Sci Rep, 2019 May 27. PMID 31133639, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of collateral sprouting in absence of injury IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of collateral sprouting in absence of injury IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    34484780..34522237 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009306176.3 → XP_009304451.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    See identical proteins and their annotated locations for XP_009304451.1

    UniProtKB/TrEMBL
    A0A8M3BDU2, F1QAD7
    Related
    ENSDARP00000138914.1, ENSDART00000158616.2
    Conserved Domains (5) summary
    cd08398
    Location:325 → 484
    C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
    smart00143
    Location:31 → 108
    PI3K_p85B; PI3-kinase family, p85-binding domain
    cd00872
    Location:529 → 696
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    pfam00794
    Location:173 → 292
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl21453
    Location:695 → 1065
    PKc_like; Protein Kinases, catalytic domain

  2. XM_009306177.3 → XP_009304452.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    See identical proteins and their annotated locations for XP_009304452.1

    UniProtKB/TrEMBL
    A0A8M3BDU2, F1QAD7
    Related
    ENSDARP00000148626.1, ENSDART00000188223.1
    Conserved Domains (5) summary
    cd08398
    Location:325 → 484
    C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
    smart00143
    Location:31 → 108
    PI3K_p85B; PI3-kinase family, p85-binding domain
    cd00872
    Location:529 → 696
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    pfam00794
    Location:173 → 292
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl21453
    Location:695 → 1065
    PKc_like; Protein Kinases, catalytic domain

  3. XM_021479874.1 → XP_021335549.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    UniProtKB/TrEMBL
    A0A8M3BDU2, F1QAD7
    Related
    ENSDARP00000103176.3, ENSDART00000114004.5
    Conserved Domains (5) summary
    cd08398
    Location:325 → 484
    C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
    smart00143
    Location:31 → 108
    PI3K_p85B; PI3-kinase family, p85-binding domain
    cd00872
    Location:529 → 696
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    pfam00794
    Location:173 → 292
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl21453
    Location:695 → 1065
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.