htr1b 5-hydroxytryptamine (serotonin) receptor 1B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: htr1bprovided by ZNC
Official Full Name: 5-hydroxytryptamine (serotonin) receptor 1Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-081022-141
See related: Ensembl:ENSDARG00000053987 AllianceGenome:ZFIN:ZDB-GENE-081022-141
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:194666; zgc:194690
Summary: Predicted to enable G protein-coupled serotonin receptor activity; neurotransmitter receptor activity; and serotonin binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting serotonin receptor signaling pathway; and chemical synaptic transmission. Predicted to act upstream of or within several processes, including G protein-coupled receptor signaling pathway; bone remodeling; and vasoconstriction. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in central nervous system; pharynx; and retina. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and conduct disorder. Orthologous to human HTR1B (5-hydroxytryptamine receptor 1B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (36588281..36589605)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (36640696..36642020)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	IEA Inferred from Electronic Annotation more info
enables alpha2-adrenergic receptor activity	IEA Inferred from Electronic Annotation more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone remodeling	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasoconstriction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.