tshr thyroid stimulating hormone receptor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tshrprovided by ZNC
Official Full Name: thyroid stimulating hormone receptorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-110524-4
See related: Ensembl:ENSDARG00000037195 AllianceGenome:ZFIN:ZDB-GENE-110524-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Enables thyroid-stimulating hormone receptor activity. Acts upstream of or within skeletal system development. Predicted to be located in basolateral plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in thyroid follicle and thyroid primordium. Used to study hyperthyroidism. Human ortholog(s) of this gene implicated in Graves' disease; cardiomyopathy; congenital nongoitrous hypothyroidism 1; and mitral valve prolapse. Orthologous to human TSHR (thyroid stimulating hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (6035427..6079923)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (5993528..6036439)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional thyroid differentiation in zebrafish was examined and the role of TSHR signaling during thyroid organogenesis, was characterized.
Title: TSH receptor function is required for normal thyroid differentiation in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables protein-hormone receptor activity	IEA Inferred from Electronic Annotation more info
enables thyroid-stimulating hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables thyroid-stimulating hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables thyroid-stimulating hormone receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in activation of adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thyrotropin receptor

Names: TSH receptor; manet; opallus

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145763.2 → NP_001139235.1 thyrotropin receptor precursor

See identical proteins and their annotated locations for NP_001139235.1

Status: PROVISIONAL

Source sequence(s)

EF487539

UniProtKB/TrEMBL

C0SKM5

Related

ENSDARP00000054085.4, ENSDART00000054086.5

Conserved Domains (3) summary

sd00033
Location:52 → 75

LRR_RI; leucine-rich repeat [structural motif]

pfam00001
Location:446 → 677

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam13306
Location:101 → 224

LRR_5; Leucine rich repeats (6 copies)