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Ppie peptidylprolyl isomerase E (cyclophilin E) [ Mus musculus (house mouse) ]

Gene ID: 56031, updated on 21-Apr-2024

Summary

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Official Symbol
Ppieprovided by MGI
Official Full Name
peptidylprolyl isomerase E (cyclophilin E)provided by MGI
Primary source
MGI:MGI:1917118
See related
Ensembl:ENSMUSG00000028651 AllianceGenome:MGI:1917118
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cyp33; 2010010D16Rik
Summary
Predicted to enable RNA binding activity; cyclosporin A binding activity; and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in several processes, including mRNA splicing, via spliceosome; positive regulation of viral genome replication; and protein peptidyl-prolyl isomerization. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in cytosol and nuclear speck. Predicted to be part of U2-type catalytic step 2 spliceosome. Predicted to be active in cytoplasm. Is expressed in brain; cerebral cortex; and olfactory epithelium. Orthologous to human PPIE (peptidylprolyl isomerase E). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 21.0), limb E14.5 (RPKM 14.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.2; 4 57.39 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (123020907..123033783, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (123127114..123139990, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4662 Neighboring gene STARR-positive B cell enhancer ABC_E4663 Neighboring gene predicted gene 12923 Neighboring gene predicted gene, 46868 Neighboring gene bone morphogenetic protein 8b Neighboring gene predicted gene, 17244 Neighboring gene 3-oxoacid CoA transferase 2B Neighboring gene STARR-positive B cell enhancer ABC_E8988 Neighboring gene STARR-seq mESC enhancer starr_11286 Neighboring gene STARR-positive B cell enhancer ABC_E10256 Neighboring gene hippocalcin-like 4 Neighboring gene 5'-nucleotidase, cytosolic IA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gene structure and evolution of testicular haploid germ cell-specific genes, Oxct2a and Oxct2b. Onishi M, et al. Genomics, 2004 Apr. PMID 15028287
  2. A new family of cyclophilins with an RNA recognition motif that interact with members of the trx/MLL protein family in Drosophila and human cells. Anderson M, et al. Dev Genes Evol, 2002 Apr. PMID 11976948
  3. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  4. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclosporin A binding ISO
Inferred from Sequence Orthology
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables poly(A) binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein peptidyl-prolyl isomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of U2-type catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase E
Names
PPIase E
cyclophilin-33
rotamase E
NP_062362.1
XP_006503313.1
XP_011238883.1
XP_030109538.1
XP_036020146.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019489.6 → NP_062362.1  peptidyl-prolyl cis-trans isomerase E

    See identical proteins and their annotated locations for NP_062362.1

    Status: VALIDATED

    Source sequence(s)
    AL606934
    Consensus CDS
    CCDS18610.1
    UniProtKB/Swiss-Prot
    Q9D8C0, Q9QZH3
    Related
    ENSMUSP00000030404.5, ENSMUST00000030404.5
    Conserved Domains (3) summary
    COG0724
    Location:5 → 194
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd01926
    Location:140 → 298
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd12347
    Location:8 → 80
    RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    123020907..123033783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503250.4 → XP_006503313.1  peptidyl-prolyl cis-trans isomerase E isoform X1

    See identical proteins and their annotated locations for XP_006503313.1

    Conserved Domains (1) summary
    cd01926
    Location:56 → 214
    cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...

  2. XM_036164253.1 → XP_036020146.1  peptidyl-prolyl cis-trans isomerase E isoform X1

    Conserved Domains (1) summary
    cd01926
    Location:56 → 214
    cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...

  3. XM_011240581.2 → XP_011238883.1  peptidyl-prolyl cis-trans isomerase E isoform X1

    See identical proteins and their annotated locations for XP_011238883.1

    Conserved Domains (1) summary
    cd01926
    Location:56 → 214
    cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...

  4. XM_030253678.2 → XP_030109538.1  peptidyl-prolyl cis-trans isomerase E isoform X1

    Conserved Domains (1) summary
    cd01926
    Location:56 → 214
    cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZH3.2 GenPept UniProtKB/Swiss-Prot:Q9QZH3

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