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bmp1b bone morphogenetic protein 1b [ Danio rerio (zebrafish) ]

Gene ID: 559877, updated on 11-Apr-2024

Summary

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Official Symbol
bmp1bprovided by ZNC
Official Full Name
bone morphogenetic protein 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060818-2
See related
Ensembl:ENSDARG00000028053 AllianceGenome:ZFIN:ZDB-GENE-060818-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable calcium ion binding activity; metalloendopeptidase activity; and zinc ion binding activity. Predicted to act upstream of or within proteolysis. Is expressed in margin. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 13. Orthologous to human BMP1 (bone morphogenetic protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See bmp1b in Genome Data Viewer
Location:
chromosome: 10
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (40859256..40939360, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (40938070..41018171, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene proliferating cell nuclear antigen Neighboring gene tripartite motif containing 69 Neighboring gene neuropeptide FF receptor 1 like 1 Neighboring gene ANTXR cell adhesion molecule 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling. Yabe T, et al. Development, 2003 Jun. PMID 12736214
  2. Genome-wide comparative analysis ofbone morphogenetic proteins: genomic structure, phylogeny, and expression patterns in the golden pompano,Trachinotus ovatus(Linnaeus, 1758). Sun J, et al. Fish Physiol Biochem, 2020 Feb. PMID 31680186
  3. Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein. Muraoka O, et al. Nat Cell Biol, 2006 Apr. PMID 16518392
  4. Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma. Venkatesan AM, et al. J Clin Invest, 2018 Jan 2. PMID 29202482, Free PMC Article
  5. Genome wide identification, phylogeny, and expression of bone morphogenetic protein genes in tetraploidized common carp (Cyprinus carpio). Chen L, et al. Gene, 2017 Sep 5. PMID 28627438

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dorsal/ventral pattern formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
bone morphogenetic protein 1b
NP_001034901.1
XP_005155463.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039812.1 → NP_001034901.1  bone morphogenetic protein 1b precursor

    See identical proteins and their annotated locations for NP_001034901.1

    Status: PROVISIONAL

    Source sequence(s)
    AB239772
    UniProtKB/TrEMBL
    Q2ABP0
    Related
    ENSDARP00000150088.1, ENSDART00000190510.1
    Conserved Domains (5) summary
    smart00179
    Location:530 → 570
    EGF_CA; Calcium-binding EGF-like domain
    cd04281
    Location:109 → 303
    ZnMc_BMP1_TLD; Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, ...
    pfam00431
    Location:418 → 527
    CUB; CUB domain
    pfam01400
    Location:111 → 303
    Astacin; Astacin (Peptidase family M12A)
    pfam14670
    Location:690 → 725
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    40859256..40939360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005155406.4 → XP_005155463.1  bone morphogenetic protein 1b isoform X1

    UniProtKB/TrEMBL
    A0A8M2B1Y0
    Related
    ENSDARP00000059794.8, ENSDART00000059795.8
    Conserved Domains (5) summary
    smart00179
    Location:530 → 570
    EGF_CA; Calcium-binding EGF-like domain
    cd04281
    Location:109 → 303
    ZnMc_BMP1_TLD; Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, ...
    pfam00431
    Location:418 → 527
    CUB; CUB domain
    pfam01400
    Location:111 → 303
    Astacin; Astacin (Peptidase family M12A)
    pfam14670
    Location:691 → 726
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein
Heading Accession and Version

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