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prmt2 protein arginine methyltransferase 2 [ Danio rerio (zebrafish) ]

Gene ID: 558841, updated on 11-Apr-2024

Summary

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Official Symbol
prmt2provided by ZNC
Official Full Name
protein arginine methyltransferase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-041104-1
See related
Ensembl:ENSDARG00000063212 AllianceGenome:ZFIN:ZDB-GENE-041104-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hrmt1l1; zgc:158247; si:ch211-226c11.1
Summary
Enables identical protein binding activity. Predicted to act upstream of or within peptidyl-arginine methylation. Orthologous to human PRMT2 (protein arginine methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (9953063..9961004, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (9981690..9989627, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene follistatin-like 1b Neighboring gene transcription termination factor, RNA polymerase II Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A1 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 Neighboring gene UDP glucuronosyltransferase 1 family a, b Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A4 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A5 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A7 Neighboring gene neurexophilin 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors. Cura V, et al. FEBS J, 2017 Jan. PMID 27879050
  2. Identification and phylogenetic analyses of the protein arginine methyltransferase gene family in fish and ascidians. Hung CM, et al. Gene, 2004 Oct 13. PMID 15475159
  3. Molecular characterisation and inductive expression of a fish protein arginine methyltransferase 1 gene in response to virus infection. Dong CW, et al. Fish Shellfish Immunol, 2007 Apr. PMID 17055744
  4. Understanding the complexity of epimorphic regeneration in zebrafish caudal fin tissue: A transcriptomic and proteomic approach. Banu S, et al. Genomics, 2022 Mar. PMID 35134499
  5. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PRMT2 is a modular protein containing a catalytic Ado-Met-binding domain and unique Src homology 3 domain that binds proteins with proline-rich motifs.
    Title: Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC158247

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables S-adenosylmethionine-dependent methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables histone methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-arginine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-arginine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein arginine N-methyltransferase 2
Names
HMT1 hnRNP methyltransferase-like 1
NP_001073644.2
XP_021334365.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080175.2 → NP_001073644.2  protein arginine N-methyltransferase 2

    Status: VALIDATED

    Source sequence(s)
    AL954329, CT641169, EH521555
    UniProtKB/TrEMBL
    A0A8M1NCQ6, A1L1Q4, F1QDD1
    Related
    ENSDARP00000086597.3, ENSDART00000092164.4
    Conserved Domains (3) summary
    cd02440
    Location:119 → 216
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cd11806
    Location:14 → 66
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    pfam05185
    Location:118 → 381
    PRMT5; PRMT5 arginine-N-methyltransferase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    9953063..9961004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478690.1 → XP_021334365.1  protein arginine N-methyltransferase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QJP4, A1L1Q4
    Conserved Domains (2) summary
    cd02440
    Location:60 → 157
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    pfam05185
    Location:59 → 322
    PRMT5; PRMT5 arginine-N-methyltransferase
Nucleotide Protein Strain
Heading Accession and Version

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