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PBK PDZ binding kinase [ Homo sapiens (human) ]

Gene ID: 55872, updated on 5-Mar-2024

Summary

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Official Symbol
PBKprovided by HGNC
Official Full Name
PDZ binding kinaseprovided by HGNC
Primary source
HGNC:HGNC:18282
See related
Ensembl:ENSG00000168078 MIM:611210; AllianceGenome:HGNC:18282
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPK; CT84; TOPK; HEL164; Nori-3
Summary
This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Biased expression in testis (RPKM 35.2), lymph node (RPKM 5.8) and 8 other tissues See more
Orthologs
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Genomic context

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See PBK in Genome Data Viewer
Location:
8p21.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (27809624..27837817, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (28086996..28115148, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (27667141..27695334, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986934 Neighboring gene uncharacterized LOC124902093 Neighboring gene coiled-coil domain containing 25 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19051 Neighboring gene RNA, U6 small nuclear 1276, pseudogene Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 2 Neighboring gene MPRA-validated peak6971 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27158 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa pseudogene Neighboring gene SCARA5 intron CAGE-defined high expression enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27735141-27735642 Neighboring gene scavenger receptor class A member 5 Neighboring gene microRNA 4287

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TOPK promotes the growth of esophageal cancer in vitro and in vivo by enhancing YB1/eEF1A1 signal pathway. Wu W, et al. Cell Death Dis, 2023 Jun 16. PMID 37328464, Free PMC Article
  2. TOPK inhibits TNF-α-induced granulosa cell apoptosis via regulation of SIRT1/p53. Joo NR, et al. Biochem Biophys Res Commun, 2023 Jul 5. PMID 37148702
  3. PDZ-binding kinase aggravates pancreatic neuroendocrine neoplasm progression by activating the AKT/mTOR pathway. Feng T, et al. Mol Carcinog, 2023 May. PMID 36807309
  4. Overexpression of PBK/TOPK relates to poor prognosis of patients with breast cancer: a retrospective analysis. Qiao L, et al. World J Surg Oncol, 2022 Sep 28. PMID 36171591, Free PMC Article
  5. PBK drives PARP inhibitor resistance through the TRIM37/NFκB axis in ovarian cancer. Ma H, et al. Exp Mol Med, 2022 Jul. PMID 35859118, Free PMC Article

See all (131) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KRAS[G12C] mutation-induced TOPK overexpression contributes to tumour progression in non-small cell lung cancer.
    Title: KRAS(G12C) mutation-induced TOPK overexpression contributes to tumour progression in non-small cell lung cancer.
  2. TOPK promotes the growth of esophageal cancer in vitro and in vivo by enhancing YB1/eEF1A1 signal pathway.
    Title: TOPK promotes the growth of esophageal cancer in vitro and in vivo by enhancing YB1/eEF1A1 signal pathway.
  3. TOPK inhibits TNF-alpha-induced granulosa cell apoptosis via regulation of SIRT1/p53.
    Title: TOPK inhibits TNF-α-induced granulosa cell apoptosis via regulation of SIRT1/p53.
  4. PDZ-binding kinase aggravates pancreatic neuroendocrine neoplasm progression by activating the AKT/mTOR pathway.
    Title: PDZ-binding kinase aggravates pancreatic neuroendocrine neoplasm progression by activating the AKT/mTOR pathway.
  5. Overexpression of PBK/TOPK relates to poor prognosis of patients with breast cancer: a retrospective analysis.
    Title: Overexpression of PBK/TOPK relates to poor prognosis of patients with breast cancer: a retrospective analysis.
  6. PBK drives PARP inhibitor resistance through the TRIM37/NFkappaB axis in ovarian cancer.
    Title: PBK drives PARP inhibitor resistance through the TRIM37/NFκB axis in ovarian cancer.
  7. TOPK Affects Autophagy of Skin Squamous Cell Carcinoma by Regulating NF-KB Pathway through HDAC1.
    Title: TOPK Affects Autophagy of Skin Squamous Cell Carcinoma by Regulating NF-KB Pathway through HDAC1.
  8. TOPK/PBK is phosphorylated by ERK2 at serine 32, promotes tumorigenesis and is involved in sorafenib resistance in RCC.
    Title: TOPK/PBK is phosphorylated by ERK2 at serine 32, promotes tumorigenesis and is involved in sorafenib resistance in RCC.
  9. Identification of PBK as a hub gene and potential therapeutic target for medulloblastoma.
    Title: Identification of PBK as a hub gene and potential therapeutic target for medulloblastoma.
  10. T-LAK cell-originated protein kinase (TOPK): an emerging prognostic biomarker and therapeutic target in osteosarcoma.
    Title: T-LAK cell-originated protein kinase (TOPK): an emerging prognostic biomarker and therapeutic target in osteosarcoma.
Submit: New GeneRIF Correction See all GeneRIFs (87)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ14385

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to UV IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of stress-activated MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in stress-activated MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lymphokine-activated killer T-cell-originated protein kinase
Names
MAPKK-like protein kinase
T-LAK cell-originated protein kinase
cancer/testis antigen 84
epididymis luminal protein 164
serine/threonine protein kinase
spermatogenesis-related protein kinase
NP_001265874.1
NP_001349969.1
NP_060962.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278945.2 → NP_001265874.1  lymphokine-activated killer T-cell-originated protein kinase isoform 2

    See identical proteins and their annotated locations for NP_001265874.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is longer, compared to isoform 1.
    Source sequence(s)
    AK301836, BC015191, DB028500
    Consensus CDS
    CCDS64858.1
    UniProtKB/Swiss-Prot
    Q96KB5
    Related
    ENSP00000428489.1, ENST00000522944.5
    Conserved Domains (2) summary
    cd14001
    Location:32 → 332
    PKc_TOPK; Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase
    pfam00069
    Location:34 → 327
    Pkinase; Protein kinase domain

  2. NM_001363040.2 → NP_001349969.1  lymphokine-activated killer T-cell-originated protein kinase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    BC015191, DC395891
    Consensus CDS
    CCDS6063.1
    UniProtKB/Swiss-Prot
    B4DX68, D3DST2, Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6
    UniProtKB/TrEMBL
    V9HWH0
    Conserved Domains (1) summary
    cd14001
    Location:32 → 321
    PKc_TOPK; Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase

  3. NM_018492.4 → NP_060962.2  lymphokine-activated killer T-cell-originated protein kinase isoform 1

    See identical proteins and their annotated locations for NP_060962.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript, and encodes the shorter isoform (1). Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    BC015191, DB028500
    Consensus CDS
    CCDS6063.1
    UniProtKB/Swiss-Prot
    B4DX68, D3DST2, Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6
    UniProtKB/TrEMBL
    V9HWH0
    Related
    ENSP00000301905.4, ENST00000301905.9
    Conserved Domains (1) summary
    cd14001
    Location:32 → 321
    PKc_TOPK; Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    27809624..27837817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    28086996..28115148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96KB5.3 GenPept UniProtKB/Swiss-Prot:Q96KB5

Gene LinkOut

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