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lpin2 lipin 2 [ Danio rerio (zebrafish) ]

Gene ID: 558422, updated on 27-Mar-2024

Summary

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Official Symbol
lpin2provided by ZNC
Official Full Name
lipin 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-060503-153
See related
Ensembl:ENSDARG00000061214 AllianceGenome:ZFIN:ZDB-GENE-060503-153
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
lipin2; si:dkey-216e9.8
Summary
Predicted to enable phosphatidate phosphatase activity and transcription coactivator activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; fatty acid catabolic process; and triglyceride biosynthetic process. Predicted to be active in cytosol; endoplasmic reticulum membrane; and nucleus. Orthologous to human LPIN2 (lipin 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (30960291..30984508)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (30976745..31000975)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene myosin, light chain 12, genome duplicate 2 Neighboring gene myomesin 1a (skelemin) Neighboring gene elastin microfibril interfacer 2a Neighboring gene uncharacterized LOC101885430

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation. Lordén G, et al. J Exp Med, 2017 Feb. PMID 28031477, Free PMC Article
  2. Fructose leads to hepatic steatosis in zebrafish that is reversed by mechanistic target of rapamycin (mTOR) inhibition. Sapp V, et al. Hepatology, 2014 Nov. PMID 25043405
  3. Comparative Study of Different Diets-Induced NAFLD Models of Zebrafish. Chen B, et al. Front Endocrinol (Lausanne), 2018. PMID 30026731, Free PMC Article
  4. Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates. Sundström G, et al. PLoS One, 2010 May 6. PMID 20463905, Free PMC Article
  5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidate phosphatase LPIN2
XP_005163511.1
XP_707850.4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    30960291..30984508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_702758.8 → XP_707850.4  phosphatidate phosphatase LPIN2 isoform X2

    UniProtKB/TrEMBL
    A0A8N7TC03, F1RAK9
    Related
    ENSDARP00000079677.6, ENSDART00000085242.6
    Conserved Domains (4) summary
    pfam15017
    Location:883 → 902
    AF1Q; Drug resistance and apoptosis regulator
    pfam04571
    Location:1 → 106
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:644 → 869
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:472 → 562
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  2. XM_005163454.4 → XP_005163511.1  phosphatidate phosphatase LPIN2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BAN1
    Conserved Domains (4) summary
    pfam15017
    Location:920 → 939
    AF1Q; Drug resistance and apoptosis regulator
    pfam04571
    Location:38 → 143
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:681 → 906
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:509 → 599
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
Nucleotide Protein Strain
Heading Accession and Version

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