adrb3a adrenoceptor beta 3a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adrb3aprovided by ZNC
Official Full Name: adrenoceptor beta 3aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-080917-21
See related: Ensembl:ENSDARG00000053646 AllianceGenome:ZFIN:ZDB-GENE-080917-21
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7154935; si:ch211-215f19.1
Summary: Predicted to enable beta3-adrenergic receptor activity; epinephrine binding activity; and norepinephrine binding activity. Predicted to be involved in adenylate cyclase-activating adrenergic receptor signaling pathway and norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in blood; brain; hatching gland; intermediate cell mass of mesoderm; and polster. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); dilated cardiomyopathy 1H; obesity; and type 2 diabetes mellitus. Orthologous to human ADRB3 (adrenoceptor beta 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (37700189..37738751)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (37667755..37706317)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables alpha2-adrenergic receptor activity	IEA Inferred from Electronic Annotation more info
enables beta3-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables epinephrine binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adrenoceptor beta 3a

Names: adrenergic receptor, beta 3a; beta-3a-adrenergic receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128335.1 → NP_001121807.1 adrenoceptor beta 3a

Status: PROVISIONAL

Source sequence(s)

CR749761

UniProtKB/TrEMBL

A0A8N1TSK4, B0UYT9, E7F0H4

Related

ENSDARP00000107786.2, ENSDART00000127633.3

Conserved Domains (2) summary

pfam00001
Location:11 → 307

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:11 → 141

7tm_4; Olfactory receptor