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borcs8 BLOC-1 related complex subunit 8 [ Danio rerio (zebrafish) ]

Gene ID: 558180, updated on 27-Mar-2024

Summary

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Official Symbol
borcs8provided by ZNC
Official Full Name
BLOC-1 related complex subunit 8provided by ZNC
Primary source
ZFIN:ZDB-GENE-050208-757
See related
Ensembl:ENSDARG00000071339 AllianceGenome:ZFIN:ZDB-GENE-050208-757
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mef2b; mef2bnb; si:ch211-125m10.2
Summary
Predicted to be located in lysosomal membrane. Predicted to be part of BORC complex. Is expressed in brain and pharyngeal arch. Orthologous to human BORCS8 (BLOC-1 related complex subunit 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 22
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (18166586..18175172)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (18141598..18150856)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene neurocan b Neighboring gene nuclear receptor 2C2-associated protein Neighboring gene regulatory factor X-associated ankyrin-containing protein Neighboring gene transmembrane protein 221 Neighboring gene myocyte enhancer factor 2b Neighboring gene transmembrane protein 161A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cabin1 expression suggests roles in neuronal development. Hammond DR, et al. Dev Dyn, 2010 Sep. PMID 20652955
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
part_of BORC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of BORC complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
BLOC-1-related complex subunit 8
Names
MEF2B neighbor gene protein homolog
mef2b neighbor gene transcript
protein MEF2BNB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098247.2 → NP_001091717.1  BLOC-1-related complex subunit 8

    See identical proteins and their annotated locations for NP_001091717.1

    Status: PROVISIONAL

    Source sequence(s)
    BC162309
    UniProtKB/Swiss-Prot
    A3KQI3, B3DG62
    Related
    ENSDARP00000096205.4, ENSDART00000105432.5
    Conserved Domains (1) summary
    pfam10167
    Location:8 → 110
    NEP; uncharacterized conserved protein

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    18166586..18175172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005170457.4 → XP_005170514.1  BLOC-1-related complex subunit 8 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BHT0
    Conserved Domains (1) summary
    pfam10167
    Location:8 → 109
    NEP; uncharacterized conserved protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A3KQI3.1 GenPept UniProtKB/Swiss-Prot:A3KQI3

Gene LinkOut

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