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itgb2 integrin, beta 2 [ Danio rerio (zebrafish) ]

Gene ID: 557797, updated on 4-Jan-2025

Summary

Official Symbol
itgb2provided by ZNC
Official Full Name
integrin, beta 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-110411-4
See related
Ensembl:ENSDARG00000016939 AllianceGenome:ZFIN:ZDB-GENE-110411-4
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-260n18.4
Summary
Predicted to enable amyloid-beta binding activity; integrin binding activity; and protein kinase binding activity. Acts upstream of with a negative effect on definitive hemopoiesis. Acts upstream of or within neutrophil migration. Predicted to be located in plasma membrane. Predicted to be part of integrin complex. Predicted to be active in cell surface and focal adhesion. Is expressed in caudal hematopoietic tissue. Human ortholog(s) of this gene implicated in coronary restenosis; leukocyte adhesion deficiency; and leukocyte adhesion deficiency 1. Orthologous to human ITGB2 (integrin subunit beta 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See itgb2 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (44962012..44983780, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (45161056..45182832, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene zgc:66484 Neighboring gene villin 1 Neighboring gene retinol saturase (all-trans-retinol 13,14-reductase) like Neighboring gene adenosine deaminase RNA specific B1b

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables amyloid-beta binding  
enables integrin binding  
enables protein kinase binding  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion  
involved_in cell adhesion mediated by integrin  
involved_in cell-matrix adhesion  
acts_upstream_of_negative_effect definitive hemopoiesis PubMed 
involved_in integrin-mediated signaling pathway  
acts_upstream_of_or_within integrin-mediated signaling pathway  
involved_in leukocyte cell-cell adhesion  
involved_in neutrophil chemotaxis  
acts_upstream_of_or_within neutrophil migration PubMed 
Component Evidence Code Pubs
is_active_in cell surface  
is_active_in focal adhesion  
part_of integrin complex  
located_in membrane  
located_in plasma membrane  

General protein information

Preferred Names
integrin beta-2
Names
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    44962012..44983780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_680920.8XP_686012.3  integrin beta-2

    UniProtKB/TrEMBL
    A0A8N7TDC7, E7FCN5
    Related
    ENSDARP00000124433.1, ENSDART00000149704.2
    Conserved Domains (4) summary
    pfam00362
    Location:32449
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:619697
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:724765
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam12785
    Location:506627
    VESA1_N; Variant erythrocyte surface antigen-1
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