bmp7b bone morphogenetic protein 7b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bmp7bprovided by ZNC
Official Full Name: bone morphogenetic protein 7bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060929-328
See related: Ensembl:ENSDARG00000063230 AllianceGenome:ZFIN:ZDB-GENE-060929-328
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:153025
Summary: Predicted to enable BMP receptor binding activity and cytokine activity. Predicted to be involved in BMP signaling pathway; SMAD protein signal transduction; and positive regulation of pathway-restricted SMAD protein phosphorylation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; fin; neuroepithelial cell; optic cup; and sensory system. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human BMP7 (bone morphogenetic protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (6421407..6522567, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (6487436..6588548, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cloning and expression of a second zebrafish bmp7 homolog, bmp7b.
Title: Identification of a BMP7 homolog in zebrafish expressed in developing organ systems.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within bone morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within iris morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of developmental pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinal pigment epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bone morphogenetic protein 7; bone morphogenetic protein 7b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077146.2 → NP_001070614.2 bone morphogenetic protein 7b

Status: VALIDATED

Source sequence(s)

BX323087, CR339064

UniProtKB/TrEMBL

A0A8M2BLR0, F1QD07, Q08CJ5

Related

ENSDARP00000086646.3, ENSDART00000092214.5

Conserved Domains (2) summary

pfam00019
Location:326 → 426

TGF_beta; Transforming growth factor beta like domain

pfam00688
Location:32 → 274

TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007134.7 Reference GRCz11 Primary Assembly

Range

6421407..6522567 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005174107.4 → XP_005174164.1 bone morphogenetic protein 7 isoform X1

UniProtKB/TrEMBL

F1QD07

Related

ENSDARP00000119798.1, ENSDART00000138020.2

Conserved Domains (2) summary

pfam00019
Location:326 → 426

TGF_beta; Transforming growth factor beta like domain

pfam00688
Location:32 → 274

TGFb_propeptide; TGF-beta propeptide