fstl3 follistatin-like 3 (secreted glycoprotein) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fstl3provided by ZNC
Official Full Name: follistatin-like 3 (secreted glycoprotein)provided by ZNC
Primary source: ZFIN:ZDB-GENE-050913-111
See related: Ensembl:ENSDARG00000025670 AllianceGenome:ZFIN:ZDB-GENE-050913-111
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:114170; si:dkey-28h18.3
Summary: Predicted to enable activin binding activity. Predicted to be involved in cell differentiation; negative regulation of activin receptor signaling pathway; and regulation of BMP signaling pathway. Predicted to be active in extracellular space. Orthologous to human FSTL3 (follistatin like 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (18884872..18893390)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (18859894..18868412)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables activin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of activin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: follistatin-related protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030111.2 → NP_001025282.2 follistatin-related protein 3 precursor

See identical proteins and their annotated locations for NP_001025282.2

Status: PROVISIONAL

Source sequence(s)

BC134879

UniProtKB/TrEMBL

A0A8M1N7D3, A4IG14

Related

ENSDARP00000155619.1, ENSDART00000186332.1

Conserved Domains (2) summary

smart00280
Location:111 → 158

KAZAL; Kazal type serine protease inhibitors

cd00104
Location:201 → 234

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...