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prkd3 protein kinase D3 [ Danio rerio (zebrafish) ]

Gene ID: 557337, updated on 11-Apr-2024

Summary

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Official Symbol
prkd3provided by ZNC
Official Full Name
protein kinase D3provided by ZNC
Primary source
ZFIN:ZDB-GENE-130530-880
See related
Ensembl:ENSDARG00000079967 AllianceGenome:ZFIN:ZDB-GENE-130530-880
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable ATP binding activity; calcium-dependent protein kinase C activity; and metal ion binding activity. Predicted to be involved in protein kinase D signaling. Predicted to act upstream of or within intracellular signal transduction and protein phosphorylation. Predicted to be located in cytoplasm and membrane. Orthologous to human PRKD3 (protein kinase D3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 17
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (42613378..42799315, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (42337975..42523775, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene linc RNA alien Neighboring gene forkhead box A2 Neighboring gene molybdenum cofactor synthesis 3 Neighboring gene glutaminyl-peptide cyclotransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comparative analysis of the human and zebrafish kinomes: focus on the development of kinase inhibitors. Wlodarchak N, et al. Trends Cell Mol Biol, 2015. PMID 27011661, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase D3
Names
zmp:0000000877
XP_009291516.1
XP_021323141.1
XP_685483.4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    42613378..42799315 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009293241.3 → XP_009291516.1  serine/threonine-protein kinase D3 isoform X2

    UniProtKB/TrEMBL
    A0A8M3B2L1
    Conserved Domains (5) summary
    smart00220
    Location:580 → 832
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:269 → 318
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01239
    Location:405 → 532
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:572 → 831
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    pfam00130
    Location:153 → 202
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  2. XM_680391.8 → XP_685483.4  serine/threonine-protein kinase D3 isoform X1

    UniProtKB/TrEMBL
    A0A8N7T5E5, E7F9Z2
    Related
    ENSDARP00000128712.1, ENSDART00000154755.2
    Conserved Domains (5) summary
    smart00220
    Location:581 → 833
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:270 → 319
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01239
    Location:406 → 533
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:573 → 832
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    pfam00130
    Location:153 → 202
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  3. XM_021467466.1 → XP_021323141.1  serine/threonine-protein kinase D3 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PLK0
    Conserved Domains (3) summary
    cd00029
    Location:13 → 62
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01239
    Location:149 → 276
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:316 → 575
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
Nucleotide Protein Strain
Heading Accession and Version

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