abcg5 ATP-binding cassette, sub-family G (WHITE), member 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: abcg5provided by ZNC
Official Full Name: ATP-binding cassette, sub-family G (WHITE), member 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-050517-40
See related: Ensembl:ENSDARG00000063078 AllianceGenome:ZFIN:ZDB-GENE-050517-40
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable ATP binding activity and ATPase-coupled transmembrane transporter activity. Predicted to be involved in cholesterol homeostasis. Predicted to be located in membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in arteriosclerosis and sitosterolemia. Orthologous to human ABCG5 (ATP binding cassette subfamily G member 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (10945437..10968290)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (10812962..10835815)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cholesterol efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of ATP-binding cassette (ABC) transporter complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ATP-binding cassette sub-family G member 5

Names: sterolin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128690.1 → NP_001122162.1 ATP-binding cassette sub-family G member 5

See identical proteins and their annotated locations for NP_001122162.1

Status: PROVISIONAL

Source sequence(s)

BC162236

UniProtKB/TrEMBL

A0A2R8PWW2, B3DG12, F6NPL0

Related

ENSDARP00000086278.4, ENSDART00000091845.5

Conserved Domains (3) summary

cd03234
Location:53 → 279

ABCG_White; White pigment protein homolog of ABCG transporter subfamily

TIGR00955
Location:50 → 645

3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

pfam01061
Location:375 → 582

ABC2_membrane; ABC-2 type transporter