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ppp2r5cb protein phosphatase 2, regulatory subunit B', gamma b [ Danio rerio (zebrafish) ]

Gene ID: 557208, updated on 27-Mar-2024

Summary

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Official Symbol
ppp2r5cbprovided by ZNC
Official Full Name
protein phosphatase 2, regulatory subunit B', gamma bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041014-4
See related
Ensembl:ENSDARG00000031200 AllianceGenome:ZFIN:ZDB-GENE-041014-4
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ppp2r5c; si:dkey-241l7.9
Summary
Predicted to enable protein phosphatase activator activity. Predicted to be involved in protein dephosphorylation. Predicted to act upstream of or within signal transduction. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Orthologous to human PPP2R5C (protein phosphatase 2 regulatory subunit B'gamma). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 20
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (53898193..53963519, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (54108747..54174080, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene iodothyronine deiodinase 3b Neighboring gene uncharacterized LOC110438168 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Effects of Lithium and 2,4-Dichlorophenol on Zebrafish: Circadian Rhythm Disorder and Molecular Effects. Xiao B, et al. Zebrafish, 2017 Jun. PMID 28318412
  2. Identification of differentially expressed genes in the zebrafish hypothalamic-pituitary axis. Toro S, et al. Gene Expr Patterns, 2009 Apr. PMID 19166982, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables protein phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein phosphatase 2, regulatory subunit B', gamma b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044821.3 → NP_001038286.2  protein phosphatase 2, regulatory subunit B', gamma b isoform 1

    See identical proteins and their annotated locations for NP_001038286.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    CR381646
    UniProtKB/TrEMBL
    A0A8M2B7T1, A4QP33, E7F6C2, Q5RG11
    Conserved Domains (2) summary
    PLN00122
    Location:395 → 496
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:87 → 490
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  2. NM_001362603.1 → NP_001349532.1  protein phosphatase 2, regulatory subunit B', gamma b isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    CR381646
    UniProtKB/TrEMBL
    A0A8M2B7U8
    Conserved Domains (1) summary
    pfam01603
    Location:32 → 437
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    53898193..53963519 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005160898.4 → XP_005160955.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X2

    UniProtKB/TrEMBL
    A0A8M2B833
    Conserved Domains (2) summary
    PLN00122
    Location:394 → 495
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:86 → 489
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  2. XM_005160897.4 → XP_005160954.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1

    UniProtKB/TrEMBL
    A4QP33
    Related
    ENSDARP00000103928.4, ENSDART00000110252.6
    Conserved Domains (2) summary
    PLN00122
    Location:395 → 496
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:87 → 490
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  3. XM_005160900.4 → XP_005160957.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X3

    Conserved Domains (1) summary
    pfam01603
    Location:32 → 437
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  4. XM_021468437.1 → XP_021324112.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4

    UniProtKB/TrEMBL
    A0A8M9P2L8, F1QSR1
    Conserved Domains (1) summary
    pfam01603
    Location:85 → 437
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  5. XM_021468438.1 → XP_021324113.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X5

    UniProtKB/TrEMBL
    A0A8M9PBS1, F1QSR1
    Conserved Domains (1) summary
    pfam01603
    Location:32 → 384
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

RNA

  1. XR_002456180.1 RNA Sequence

  2. XR_222765.4 RNA Sequence

Nucleotide Protein
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