igf2r insulin-like growth factor 2 receptor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: igf2rprovided by ZNC
Official Full Name: insulin-like growth factor 2 receptorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041014-300
See related: Ensembl:ENSDARG00000006094 AllianceGenome:ZFIN:ZDB-GENE-041014-300
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-214g8.2
Summary: Predicted to enable insulin-like growth factor binding activity. Predicted to act upstream of or within lysosomal transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in late endosome; plasma membrane; and trans-Golgi network. Is expressed in nervous system; presumptive neural retina; and somite. Human ortholog(s) of this gene implicated in diabetes mellitus (multiple); hepatocellular carcinoma; in situ carcinoma (multiple); and nephroblastoma. Orthologous to human IGF2R (insulin like growth factor 2 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 47

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (42565025..42661985)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (42668047..42763143)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the D. rerio CI-MPR harbors three glycan-binding sites that map to domains 3, 5 and 9 of its 15-domain-containing extracytoplasmic region
Title: The glycan-binding properties of the cation-independent mannose 6-phosphate receptor are evolutionary conserved in vertebrates.
The expression patterns suggest time- and tissue-specific functions for the M6P receptors, with particular evidence for roles in neural development.
Title: Mannose 6-phosphate receptors in an ancient vertebrate, zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables insulin-like growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables mannose binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lysosomal transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lysosomal transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cation-independent mannose-6-phosphate receptor

Names: CI-MPR; cation-independent mannose 6-phosphate receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039627.2 → NP_001034716.1 cation-independent mannose-6-phosphate receptor precursor

See identical proteins and their annotated locations for NP_001034716.1

Status: PROVISIONAL

Source sequence(s)

AL929119

UniProtKB/TrEMBL

A0A8M1N8B1, Q2TTK0

Related

ENSDARP00000061100.4, ENSDART00000061101.6

Conserved Domains (3) summary

pfam00040
Location:1884 → 1925

fn2; Fibronectin type II domain

pfam00878
Location:413 → 562

CIMR; Cation-independent mannose-6-phosphate receptor repeat

pfam09451
Location:52 → 177

ATG27; Autophagy-related protein 27

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

42565025..42661985

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021468430.1 → XP_021324105.1 cation-independent mannose-6-phosphate receptor isoform X1

UniProtKB/TrEMBL

A0A8M9PSQ1

Conserved Domains (2) summary

pfam00878
Location:413 → 562

CIMR; Cation-independent mannose-6-phosphate receptor repeat

cl26634
Location:163 → 302

ATG27; Autophagy-related protein 27