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pparg peroxisome proliferator-activated receptor gamma [ Danio rerio (zebrafish) ]

Gene ID: 557037, updated on 21-Apr-2024

Summary

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Official Symbol
ppargprovided by ZNC
Official Full Name
peroxisome proliferator-activated receptor gammaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-213
See related
AllianceGenome:ZFIN:ZDB-GENE-990415-213
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
PPAR[g]
Summary
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to contribute to vitamin D response element binding activity. Acts upstream of or within triglyceride homeostasis. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including adipose tissue; digestive system; female organism; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); end stage renal disease; lipodystrophy (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human PPARG (peroxisome proliferator activated receptor gamma). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: suggests misassembly
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 11
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (605456..669270, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (578958..642772, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene MKRN2 opposite strand, tandem duplicate 2 Neighboring gene TSEN2 tRNA splicing endonuclease subunit Neighboring gene synapsin IIb Neighboring gene TIMP metallopeptidase inhibitor 4, tandem duplicate 1 Neighboring gene TIMP metallopeptidase inhibitor 4, tandem duplicate 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A zebrafish pparγ gene deletion reveals a protein kinase network associated with defective lipid metabolism. Zhao Y, et al. Funct Integr Genomics, 2022 Aug. PMID 35290539
  2. Peroxisome proliferator-activated receptor γ is a target for halogenated analogs of bisphenol A. Riu A, et al. Environ Health Perspect, 2011 Sep. PMID 21561829, Free PMC Article
  3. Isobavachalcone from Angelica keiskei Inhibits Adipogenesis and Prevents Lipid Accumulation. Lee H, et al. Int J Mol Sci, 2018 Jun 6. PMID 29882838, Free PMC Article
  4. Modulation of peroxisome proliferator-activated receptors (PPARs) by PPAR(alpha)- and PPAR(gamma)-specific ligands and by 17beta-estradiol in isolated zebrafish hepatocytes. Ibabe A, et al. Toxicol In Vitro, 2005 Sep. PMID 15964169
  5. Developmental exposures to perfluorooctanesulfonic acid (PFOS) impact embryonic nutrition, pancreatic morphology, and adiposity in the zebrafish, Danio rerio. Sant KE, et al. Environ Pollut, 2021 Apr 15. PMID 33581636, Free PMC Article

See all (171) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ca[2+] homeostasis imbalance induced by Pparg: A key factor in di (2-ethylhexyl) phthalate (DEHP)-induced cardiac dysfunction in zebrafish larvae.
    Title: Ca(2+) homeostasis imbalance induced by Pparg: A key factor in di (2-ethylhexyl) phthalate (DEHP)-induced cardiac dysfunction in zebrafish larvae.
  2. A zebrafish ppargamma gene deletion reveals a protein kinase network associated with defective lipid metabolism.
    Title: A zebrafish pparγ gene deletion reveals a protein kinase network associated with defective lipid metabolism.
  3. Pparg pathway acts on cephalic neural crest to direct adipocyte differentiation at the expense of osteoblast formation
    Title: Regulation of neural crest cell fate by the retinoic acid and Pparg signalling pathways.
  4. PPAR expression, the activity of its target gene AOX, and peroxisomal biogenesis are developmentally modulated in zebrafish
    Title: Expression of peroxisome proliferator-activated receptors in zebrafish (Danio rerio) depending on gender and developmental stage.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within triglyceride homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
peroxisome proliferator-activated receptor gamma
Names
ARF6
NR1C3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131467.1 → NP_571542.1  peroxisome proliferator-activated receptor gamma

    See identical proteins and their annotated locations for NP_571542.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ839547
    UniProtKB/TrEMBL
    A6XMH6
    Conserved Domains (3) summary
    cd06932
    Location:253 → 526
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:154 → 237
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:17 → 91
    PPARgamma_N; PPAR gamma N-terminal region

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    605456..669270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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