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itgb8 integrin, beta 8 [ Danio rerio (zebrafish) ]

Gene ID: 556752, updated on 11-Apr-2024

Summary

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Official Symbol
itgb8provided by ZNC
Official Full Name
integrin, beta 8provided by ZNC
Primary source
ZFIN:ZDB-GENE-071213-3
See related
Ensembl:ENSDARG00000028222 AllianceGenome:ZFIN:ZDB-GENE-071213-3
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch1073-83d9.2
Summary
Predicted to enable integrin binding activity. Acts upstream of or within angiogenesis and endothelial cell proliferation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of integrin complex. Predicted to be active in cell surface and focal adhesion. Is expressed in head. Orthologous to human ITGB8 (integrin subunit beta 8). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 19
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (2275037..2307401)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (2439833..2476012)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene twist family bHLH transcription factor 1a Neighboring gene Fer3 like bHLH transcription factor Neighboring gene sp8 transcription factor a Neighboring gene RNA polymerase I subunit F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. βPix plays a dual role in cerebral vascular stability and angiogenesis, and interacts with integrin αvβ8. Liu J, et al. Dev Biol, 2012 Mar 1. PMID 22206757
  2. The zebrafish vitronectin receptor: characterization of integrin alphaV and beta3 expression patterns in early vertebrate development. Ablooglu AJ, et al. Dev Dyn, 2007 Aug. PMID 17626277
  3. Neuropilin 1 balances β8 integrin-activated TGFβ signaling to control sprouting angiogenesis in the brain. Hirota S, et al. Development, 2015 Dec 15. PMID 26586223, Free PMC Article
  4. A zebrafish model of foxe3 deficiency demonstrates lens and eye defects with dysregulation of key genes involved in cataract formation in humans. Krall M, et al. Hum Genet, 2018 Apr. PMID 29713869, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nrp1 in endothelial cells suppresses TGFbeta activation and signaling by forming intercellular protein complexes with beta8 integrin.
    Title: Neuropilin 1 balances β8 integrin-activated TGFβ signaling to control sprouting angiogenesis in the brain.
  2. Data suggest that a complex involving betaPix, GIT1 and integrin alpha(v)beta(8) may regulate vascular stability, cerebral angiogenesis and endothelial cell proliferation in the developing embryo.
    Title: βPix plays a dual role in cerebral vascular stability and angiogenesis, and interacts with integrin αvβ8.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within blood vessel development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vasculature development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within vasculature development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
integrin beta-8

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    2275037..2307401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021468203.1 → XP_021323878.1  integrin beta-8

    UniProtKB/TrEMBL
    A0A8M9PB88
    Related
    ENSDARP00000117882.2, ENSDART00000136138.3
    Conserved Domains (3) summary
    pfam07974
    Location:466 → 496
    EGF_2; EGF-like domain
    pfam07965
    Location:546 → 624
    Integrin_B_tail; Integrin beta tail domain
    cl00057
    Location:9 → 402
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Nucleotide Protein Strain
Heading Accession and Version

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