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mtfmt mitochondrial methionyl-tRNA formyltransferase [ Danio rerio (zebrafish) ]

Gene ID: 556680, updated on 27-Mar-2024

Summary

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Official Symbol
mtfmtprovided by ZNC
Official Full Name
mitochondrial methionyl-tRNA formyltransferaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060929-120
See related
Ensembl:ENSDARG00000005448 AllianceGenome:ZFIN:ZDB-GENE-060929-120
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mtmft; zgc:152651
Summary
Predicted to enable methionyl-tRNA formyltransferase activity. Predicted to be involved in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA. Predicted to act upstream of or within translation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 15 and nuclear type mitochondrial complex I deficiency 27. Orthologous to human MTFMT (mitochondrial methionyl-tRNA formyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (52753073..52761572)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (52478003..52486502)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene transcription factor 12 Neighboring gene zinc finger protein 280D Neighboring gene diphosphoinositol pentakisphosphate kinase 1a Neighboring gene microtubule-associated protein 1Aa

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A Primer Genetic Toolkit for Exploring Mitochondrial Biology and Disease Using Zebrafish. Sabharwal A, et al. Genes (Basel), 2022 Jul 23. PMID 35893052, Free PMC Article
  2. FusX: A Rapid One-Step Transcription Activator-Like Effector Assembly System for Genome Science. Ma AC, et al. Hum Gene Ther, 2016 Jun. PMID 26854857, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC152651

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables methionyl-tRNA formyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methionyl-tRNA formyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within conversion of methionyl-tRNA to N-formyl-methionyl-tRNA IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
methionyl-tRNA formyltransferase, mitochondrial
NP_001071010.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077542.2 → NP_001071010.2  methionyl-tRNA formyltransferase, mitochondrial

    See identical proteins and their annotated locations for NP_001071010.2

    Status: VALIDATED

    Source sequence(s)
    BC142768, BC153525
    UniProtKB/TrEMBL
    A5PL71, A8E5A7
    Related
    ENSDARP00000053813.6, ENSDART00000053814.8
    Conserved Domains (3) summary
    cd08646
    Location:53 → 246
    FMT_core_Met-tRNA-FMT_N; Methionyl-tRNA formyltransferase, N-terminal hydrolase domain
    TIGR00460
    Location:54 → 358
    fmt; methionyl-tRNA formyltransferase
    pfam02911
    Location:247 → 348
    Formyl_trans_C; Formyl transferase, C-terminal domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    52753073..52761572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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