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cdc42l2 cell division cycle 42 like 2 [ Danio rerio (zebrafish) ]

Gene ID: 556226, updated on 11-Apr-2024

Summary

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Official Symbol
cdc42l2provided by ZNC
Official Full Name
cell division cycle 42 like 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-060312-21
See related
Ensembl:ENSDARG00000057869 AllianceGenome:ZFIN:ZDB-GENE-060312-21
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:136923
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; cell projection assembly; and endocytosis. Predicted to act upstream of or within cell division and small GTPase mediated signal transduction. Human ortholog(s) of this gene implicated in fibrosarcoma. Orthologous to human CDC42 (cell division cycle 42). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See cdc42l2 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (16955672..16961280, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (17029837..17034629, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110438318 Neighboring gene F-box protein 44, tandem duplicate 7 Neighboring gene F-box protein 44, tandem duplicate 9 Neighboring gene DNA (cytosine-5-)-methyltransferase beta, duplicate b.3 Neighboring gene DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.2 Neighboring gene DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.1 Neighboring gene zinc finger-like gene 1j

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A vertebrate-specific Chp-PAK-PIX pathway maintains E-cadherin at adherens junctions during zebrafish epiboly. Tay HG, et al. PLoS One, 2010 Apr 12. PMID 20405038, Free PMC Article
  2. Developmental remodelling of non-CG methylation at satellite DNA repeats. Ross SE, et al. Nucleic Acids Res, 2020 Dec 16. PMID 33271598, Free PMC Article
  3. Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial infection. Salas-Vidal E, et al. Genomics, 2005 Jul. PMID 15894457
  4. Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components. van der Sar AM, et al. Mol Immunol, 2009 Jul. PMID 19409617
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC136923

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Cdc42 protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cell division cycle 42 like 2
Names
cdc42b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039923.1 → NP_001035012.1  cell division cycle 42 like 2

    See identical proteins and their annotated locations for NP_001035012.1

    Status: PROVISIONAL

    Source sequence(s)
    BC114307
    UniProtKB/TrEMBL
    Q29RA1
    Conserved Domains (2) summary
    smart00174
    Location:6 → 173
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cl21455
    Location:3 → 171
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    16955672..16961280 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021469813.1 → XP_021325488.1  cell division cycle 42 like 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PF26
    Conserved Domains (1) summary
    cl21455
    Location:22 → 190
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_021469814.1 → XP_021325489.1  cell division cycle 42 like 2 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PKS1
    Conserved Domains (1) summary
    cl21455
    Location:27 → 171
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_021469812.1 → XP_021325487.1  cell division cycle 42 like 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9P546, A3QJU6
    Related
    ENSDARP00000123487.1, ENSDART00000142546.2
    Conserved Domains (1) summary
    cl21455
    Location:27 → 195
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395140.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    57962..62743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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