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phka2 phosphorylase kinase, alpha 2 (liver) [ Danio rerio (zebrafish) ]

Gene ID: 556199, updated on 27-Mar-2024

Summary

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Official Symbol
phka2provided by ZNC
Official Full Name
phosphorylase kinase, alpha 2 (liver)provided by ZNC
Primary source
ZFIN:ZDB-GENE-130422-1
See related
Ensembl:ENSDARG00000030687 AllianceGenome:ZFIN:ZDB-GENE-130422-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable calmodulin binding activity. Predicted to be involved in glycogen metabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in plasma membrane. Used to study visceral heterotaxy. Human ortholog(s) of this gene implicated in glycogen storage disease and glycogen storage disease IXa. Orthologous to human PHKA2 (phosphorylase kinase regulatory subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 11
Exon count:
32
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (33872185..33919593, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (33610020..33656779, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene si:ch211-227n13.3 Neighboring gene neurexophilin 2b Neighboring gene collagen, type VI, alpha 2 Neighboring gene collagen, type VI, alpha 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis. Burkhalter MD, et al. J Clin Invest, 2019 May 16. PMID 31094706, Free PMC Article
  2. High-Resolution Proteomic Profiling Shows Sexual Dimorphism in Zebrafish Heart-Associated Proteins. Niksirat H, et al. J Proteome Res, 2021 Aug 6. PMID 34185526
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphorylase b kinase regulatory subunit alpha, liver isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    33872185..33919593 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479871.1 → XP_021335546.1  phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1

    UniProtKB/TrEMBL
    A0A8M9QI67
    Conserved Domains (2) summary
    pfam00723
    Location:8 → 437
    Glyco_hydro_15; Glycosyl hydrolases family 15
    cl25463
    Location:790 → 908
    Glyco_hydro_15; Glycosyl hydrolases family 15

  2. XM_009306167.3 → XP_009304442.1  phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X2

    UniProtKB/TrEMBL
    A0A8M3B475, F1R3D9
    Related
    ENSDARP00000072664.4, ENSDART00000078202.5
    Conserved Domains (1) summary
    pfam00723
    Location:8 → 437
    Glyco_hydro_15; Glycosyl hydrolases family 15

  3. XM_678952.9 → XP_684044.4  phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X3

    UniProtKB/TrEMBL
    A0A8N7TE73
    Conserved Domains (1) summary
    pfam00723
    Location:8 → 437
    Glyco_hydro_15; Glycosyl hydrolases family 15
Nucleotide Protein Strain
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